公开(公告)号：EP1412527A2

公开(公告)日：2004-04-28

申请号：EP02753979.0

申请日：2002-07-26

申请人： McGill University

发明人： FENG, JinLiu ,  BUSSIERE, Frédéric ,  HEKIMI, Siegfried

IPC分类号： C12Q1/68

CPC分类号： C07K14/43536 ,  A61K38/00 ,  C07K14/395 ,  C07K14/415 ,  C07K14/465 ,  C07K14/47 ,  C07K14/80

摘要： The present invention relates to the characterization of mutants in the genes isp-1 and ctb-1, which are genes that have a function at the level of cellular physiology, mitochondrial respiration and electron transport, and resistance to oxidative stress, as well as regulating developmental, behavioral, reproductive and aging rates. Mutations in the genes isp-1 and ctb-1 are also provided. These genes and the protein they encode are used in a perspective of growth and aging control and in a therapeutic perspective for diseases in which mitochondrial function is altered. There is also provided methods of identification of compounds for the manipulation of the function of the isp-1 and ctb-1 genes and their protein products, as well as for the manipulation of the functions of mitochondria.