公开(公告)号：EP2717345A4

公开(公告)日：2014-11-05

申请号：EP12792862

申请日：2012-05-16

申请人： SONY CORP

发明人： TOKITA YUICHI ,  GOTO YOSHIO ,  LUO WEI ,  NAKAMARU SATOSHI ,  YAMADA SEIJI

IPC分类号： H01L51/40 ,  C07K14/80 ,  H01L21/331 ,  H01L29/73 ,  H01L29/74 ,  H01L31/10 ,  H01L51/05 ,  H01L51/30 ,  H01L51/42

CPC分类号： H01L51/0093 ,  B82Y10/00 ,  C07K14/80 ,  H01L51/4253 ,  H01L51/50 ,  Y02E10/549 ,  Y02P70/521

公开(公告)号：EP2435483B1

公开(公告)日：2014-09-17

申请号：EP10726601.7

申请日：2010-05-26

申请人： Ramot at Tel-Aviv University Ltd.

发明人： NELSON, Nathan ,  YACOBY, Iftach ,  GAZIT, Ehud ,  BENHAR, Itai

IPC分类号： C07K19/00 ,  C12M1/113 ,  C12N15/63 ,  C12R1/01 ,  C12M1/107

CPC分类号： C12P3/00 ,  C07K14/80 ,  C12N9/0077

公开(公告)号：EP2706120A1

公开(公告)日：2014-03-12

申请号：EP12183209.1

申请日：2012-09-05

申请人： Karlsruher Institut für Technologie

发明人： Buecking, Clemens ,  Goltsch, Frederik ,  Gescher, Johannes

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12N9/00 ,  C12N15/00 ,  G01N27/00

CPC分类号： C12Q1/005 ,  C07K14/80 ,  C12Q1/26 ,  G01N33/0047

摘要： The invention relates to a nucleic acid construct for detecting a compound comprising a coding region and a regulatory element, which controls expression of the coding region depending on the compound and to a cell comprising such a construct. In addition, the invention relates to a method for detecting a compound in a sample. The invention further relates to a biosensor for detecting a compound comprising an electrode system, a device for measuring electron transfer in the electrode system, and a microorganism.

摘要翻译： 本发明涉及用于检测包含编码区和调节元件的化合物的核酸构建体，其控制取决于化合物的编码区的表达和包含这种构建体的细胞。 此外，本发明涉及一种检测样品中化合物的方法。 本发明还涉及用于检测包括电极系统的化合物的生物传感器，用于测量电极系统中的电子转移的装置和微生物。

公开(公告)号：EP2589659A1

公开(公告)日：2013-05-08

申请号：EP12198197.1

申请日：2010-04-30

申请人： Ikeda Food Research Co. Ltd.

发明人： Takenaka, Ryo ,  Honda, Michinari ,  Omura, Hironori

IPC分类号： C12N15/09 ,  C07K14/38 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/04 ,  C12P21/02 ,  C12Q1/00 ,  G01N27/327 ,  H01M8/16 ,  A61B5/145

CPC分类号： H01M8/16 ,  A61B5/14532 ,  A61B5/1486 ,  C07K14/80 ,  C12N9/0006 ,  C12N15/62 ,  C12Q1/004 ,  Y02E60/527

摘要： The problem to be resolved is to provide an electron mediator and a fusion body with high affinity with an enzyme, a measuring method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor.
The present invention relates to an electron mediator for glucose oxidoreductase comprising extracellular secretion type cytochrome, a fusion body in which the electron mediator is fused with glucose oxidoreductase, a composition for glucose measurement including the electron mediator or fusion body, a gene encoding a new extracellular secretion type cytochrome, and a measurement method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor.

摘要翻译： 要解决的问题是提供与酶具有高亲和力的电子介体和融合体，使用细胞外分泌型细胞色素的测定方法，酶，电极和传感器。 本发明涉及包含细胞外分泌型细胞色素的葡萄糖氧化还原酶的电子介体，其中电子介体与葡萄糖氧化还原酶融合的融合体，包含电子介体或融合体的葡萄糖测定用组合物，编码新细胞外基因的基因 分泌型细胞色素，以及使用细胞外分泌型细胞色素和酶，电极和传感器的测定方法。

公开(公告)号：EP1882039A2

公开(公告)日：2008-01-30

申请号：EP06770687.9

申请日：2006-05-19

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Ananda ,  GUPTA, Tapas, Das ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  HONG, Chang, Soo

IPC分类号： C12P21/04

CPC分类号： C07K14/80 ,  A61K38/00 ,  C07K14/195 ,  Y02A50/386 ,  Y02A50/411 ,  Y02A50/466

摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.

公开(公告)号：EP1573324A4

公开(公告)日：2007-08-01

申请号：EP03813446

申请日：2003-12-15

申请人： ELIXIR PHARMACEUTICALS INC

发明人： HUBER JULIE L ,  SOLOMON JONATHAN M

IPC分类号： C07K14/80 ,  C12N9/80 ,  C12Q1/48 ,  G01N33/566 ,  G01N33/68 ,  G01N33/53 ,  A61K38/00 ,  C12Q1/34 ,  C12Q1/68

CPC分类号： C12Q1/48 ,  C07K14/80 ,  C12N9/80 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5079 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/6872 ,  G01N2510/00

摘要： Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or mitochondrial function such as respiration.

公开(公告)号：EP1315738A4

公开(公告)日：2006-06-07

申请号：EP01968707

申请日：2001-09-07

申请人： GRYPHON THERAPEUTICS INC

发明人： BOTTI PAOLO ,  BRADBURNE JAMES A ,  KENT STEPHEN B H ,  LOW DONALD W

IPC分类号： C07K1/00 ,  C07K5/04 ,  A61K38/00 ,  C07K1/04 ,  C07K1/08 ,  C07K5/06 ,  C07K5/068 ,  C07K5/078 ,  C07K5/087 ,  C07K7/04 ,  C07K7/06 ,  C07K14/00 ,  C07K14/505 ,  C07K14/80 ,  C12N9/02

CPC分类号： C07K14/80 ,  C07K5/06026 ,  C07K5/06086 ,  C07K5/06147 ,  C07K5/0812 ,  C07K7/06

摘要： The invention is directed to methods and compositions for chemical ligation of components comprising a first component having a carboxythioester, and preferable an alpha -carboxythioester, moiety and a second component having an N-substituted, and preferably an N alpha -substituted, 2 or 3 carbon chain alkyl or aryl thiol to give a ligation product having an N-substituted amide bond at the ligation site. The reactants of the invention are chemoselective, and the alkyl or aryl thiol moiety is removable from the ligation product. Removal of the alkyl or aryl thiol gives a native amide bond at the ligation site. The methods and compositions of the invention are particularly useful for ligation of peptides and polypeptides. The ligation system of the invention is applicable to a wide variety of molecules, and thus can be exploited to generate peptides, polypeptides and other amino acid containing polymers having a native amide bond at the ligation site.

公开(公告)号：EP1653990A1

公开(公告)日：2006-05-10

申请号：EP04780764.9

申请日：2004-08-10

申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Amanda, M. ,  DAS GUPTA, Tapas, K. ,  PUNJ, Vasu ,  ZABORINA, Olga ,  HIRAOKA, Yoshinori ,  YAMADA, Tohru

IPC分类号： A61K38/16 ,  A61P35/00

CPC分类号： C07K14/80 ,  A61K38/164 ,  A61K38/168 ,  A61K38/415 ,  C07K14/195

摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-­related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cylotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

公开(公告)号：EP0595948A1

公开(公告)日：1994-05-11

申请号：EP92916070.0

申请日：1992-07-15

申请人： Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： POMPON, Denis 9, place du Marché-neuf ,  CULLIN, Christophe ,  TRUAN, Gilles ,  URBAN, Philippe ,  SLONIMSKI, Piotr Résidence du CNRS, Bât. ABC

IPC分类号： C07K14 ,  C12N1 ,  C12N9 ,  C12N15

CPC分类号： C12N9/0042 ,  C07K14/80 ,  C12N1/18 ,  C12N9/0004 ,  C12N9/16 ,  C12N15/81

摘要： La présente invention a pour objet une souche de levure dans les chromosomes de laquelle sont intégrés de façon stable plusieurs gènes hétérologues et permettant leur expression caractérisée en ce que: (1) la souche de levure est une souche diploïde dont les allèles sont totalement isogéniques à l'exception des loci qui portent les gènes hétérologues et du locus sexuel, (2) les loci hétérozygotes sont dépourvus d'allèles portant un gène sauvage, (3) les gènes hétérologues sont placés sous le contrôle d'un promoteur inductible et régulable.

公开(公告)号：EP0199331B1

公开(公告)日：1989-09-06

申请号：EP86105507.7

申请日：1986-04-21

申请人： Brantl, Victor, Dr. med., Dipl.-Chem.

发明人： Brantl, Victor, Dr. med., Dipl.-Chem.

IPC分类号： C07K7/06 ,  C07K5/10 ,  A61K37/02 ,  G01N33/53

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1016 ,  C07K14/80