公开(公告)号：EP1987161A2

公开(公告)日：2008-11-05

申请号：EP07718355.6

申请日：2007-01-18

申请人： McGill University

发明人： HOLLMANN, Annette, C. ,  SLADEK, Robert ,  OWENS, Trevor, c/o University of Southern Denmark ,  HUDSON, Thomas, J.

IPC分类号： C12Q1/68 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/574 ,  C07K16/18 ,  C07K14/705 ,  C07K16/40 ,  C12N15/12

CPC分类号： G01N33/6863 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2333/70578 ,  G01N2510/00

摘要： A method of differentiating between first diffuse large cell B lymphoma (DLCBL) cells and second DLCBL cells, known to respond to CD40 mediated apoptosis, based on differences in expression of one or more genes or a profile of genes and a method to differentiate between CD40 sensitive and CD40 resistant DLCBL cells based on the differences in gene expression of recombination activating gene 1(RAG 1), pre-B lymphocyte gene 1 (VPREB 1), lymphocyte specific protein tyrosine kinase (LCK) and VAV 1 oncogene (VAV 1).