公开(公告)号：EP2426212A1

公开(公告)日：2012-03-07

申请号：EP11179000.2

申请日：2007-02-15

申请人： Md Bioalpha Co., Ltd.

发明人： Park, Myung-Gyu ,  Yoo, Sang-Ku ,  Jo, In Geun ,  Kwak, Taehwan

IPC分类号： C12Q1/26

CPC分类号： C12Q1/26 ,  A61K31/12 ,  A61K31/343 ,  A61K38/44 ,  C12Y106/05002

摘要： The present invention provides a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochrondrial dysfunction-related diseases, via elevation of an NAD(P) + ZNAD(P)H ratio by increasing an NAD(P) + concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinine oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.

摘要翻译： 本发明提供一种能够通过升高NAD（P）+ ZNAD（P）H比例来有效治疗与能量过量相关的各种疾病，例如肥胖症，糖尿病，代谢综合征，退行性疾病和线粒体功能障碍相关疾病的方法 通过使用NAD（P）H作为底物或通过氧化还原酶如NAD（P）H：奎宁氧化还原酶（NQO1）的氧化还原酶的辅酶，在体内或体外增加NAD（P）+浓度， 相同和治疗药物。