公开(公告)号：EP2538803A1

公开(公告)日：2013-01-02

申请号：EP11706451.9

申请日：2011-02-24

申请人： Mead Johnson Nutrition Company

发明人： ALVEY, John ,  GONZALEZ, Juan M. ,  TAYLOR, Bradley J. ,  MORRIS, Kristin L. ,  ANTHONY, Joshua C. ,  TUCKER, Hugh N. ,  POELS, Eduard K.

IPC分类号： A23L1/30 ,  A23L1/305 ,  A61P1/00 ,  A61K31/195 ,  A61K31/202

CPC分类号： A23L33/21 ,  A23L29/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/32 ,  A23V2250/1868 ,  A23V2250/1862 ,  A23V2250/54242

摘要： The present disclosure provides formulations and methods for delivering water-soluble and lipid-soluble nutrients for preventing or correcting nutrient deficiencies to subjects requiring small-volume nutritional support, such as preterm infants. The formulations may comprise an emulsion of docosahexaenoic acid (DHA) stabilized by a protein emulsifier, such as alpha-lactalbumin, and may further comprise other valuable nutrients, such as arachidonic acid (ARA), arginine, glutamine, arginyl-glutamine dipeptide and/or alanyl-glutamine dipeptide. The formulation is useful, for example, for correcting nutritional deficiencies by increasing a subject's intake of nutrients such as omega-3 or omega-6 long-chain polyunsaturated acids, proteins, peptides, vitamins, minerals, other fatty acids, and/or essential amino acids. The nutritional formulation is suitable for enteral delivery and small-volume delivery via nasogastric tube, intragastric feeding, transpyloric administration and/or any other means of administration that result in the introduction of the nutritional formulation into the digestive tract of a subject.

摘要翻译： 本公开提供了用于递送水溶性和脂溶性营养物以预防或校正需要小量营养支持的受试者（例如早产儿）的营养缺乏的制剂和方法。 制剂可以包含通过蛋白质乳化剂如α-乳白蛋白稳定的二十二碳六烯酸（DHA）的乳液，并且还可以包含其它有价值的营养物质，例如花生四烯酸（ARA），精氨酸，谷氨酰胺，精氨酰 - 谷氨酰胺二肽和/ 或丙氨酰 - 谷氨酰胺二肽。 该制剂是有用的，例如，通过增加受试者摄入的营养物质，例如ω-3或ω-6长链多不饱和酸，蛋白质，肽，维生素，矿物质，其它脂肪酸和/或必需物质 氨基酸。 营养制剂适合于通过鼻胃管进行肠内输送和小批量输送，胃内喂养，转基因施用和/或导致将营养制剂引入受试者的消化道的任何其它施用方式。