公开(公告)号：EP2341075A1

公开(公告)日：2011-07-06

申请号：EP10010678.0

申请日：2001-03-01

申请人： MedImmune, LLC ,  Applied Molecular Evolution Inc.

发明人： Young, James F. ,  Koenig, Scott ,  Johnson, Leslie S. ,  Huse, William D. ,  Wu, Herren ,  Watkins, Jeffry D.

IPC分类号： C07K16/00 ,  C07K16/10 ,  A61K39/395 ,  A61P31/00

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/567

摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for production of high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.

公开(公告)号：EP2341074A1

公开(公告)日：2011-07-06

申请号：EP10010677.2

申请日：2001-03-01

申请人： MedImmune, LLC ,  Applied Molecular Evolution Inc.

发明人： Young, James F. ,  Koenig, Scott ,  Johnson, Leslie S. ,  Huse, William D. ,  Wu, Herren ,  Watkins, Jeffry D.

IPC分类号： C07K16/00 ,  C07K16/10 ,  A61K39/395 ,  A61P31/00

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/567

摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for production of high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.

摘要翻译： 公开了具有高动力学结合速率常数和任选的高亲和力的高效价抗体，包括其免疫活性片段，以及用于产生此类抗体的方法。 本文公开的高效价抗体是中和或非中和类型，并且对由微生物，特别是病毒显示的抗原以及存在于癌细胞和各种类型的毒素上的抗原性位点以及毒素产物具有特异性。 还描述了生产高效中和抗体和增加现有中和抗体的效力的方法。 公开了使用所述抗体预防和/或治疗疾病，特别是由病毒诱发或引起的疾病的方法。

公开(公告)号：EP2338512A1

公开(公告)日：2011-06-29

申请号：EP10010675.6

申请日：2001-11-28

申请人： MedImmune, LLC

发明人： Young, James F. ,  Koenig, Scott ,  Johnson, Leslie S. ,  Watkins, Jeffry D. ,  Huse, William D. ,  Wu, Herren

IPC分类号： A61K39/395 ,  A61K39/42 ,  A61K39/00 ,  A61K39/155 ,  C12Q1/70

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject.; The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a SRV antigen, and methods using said compositions for detection or diagnosis a RSV infection.

公开(公告)号：EP2289550A3

公开(公告)日：2012-02-15

申请号：EP10007381.6

申请日：2001-01-26

申请人： MedImmune, LLC

发明人： Young, James F. ,  Johnson, Leslie S. ,  Huse, William D. ,  Wu, Herren ,  Watkins, Jeffrey D. ,  Koenig, Scott

IPC分类号： C07K16/00 ,  C07K16/10 ,  A61K39/42 ,  A61P31/12 ,  A61P31/14

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： Ultra high affinity antibodies with binding affinities in the range of 10 10 M -1 , and even 10 11 M -1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

公开(公告)号：EP2412384A1

公开(公告)日：2012-02-01

申请号：EP10010676.4

申请日：2001-11-28

申请人： MedImmune, LLC

发明人： Young, James, F. ,  Koenig, Scott ,  Johnson, Leslie, S. ,  Watkins, Jeffry, D. ,  Huse, William, D. ,  Wu, Herren

IPC分类号： A61K39/395 ,  A61K39/42 ,  A61K39/00 ,  A61K39/155 ,  C12Q1/70 ,  C07K16/10

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject.; The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a SRV antigen, and methods using said compositions for detection or diagnosis a RSV infection.

摘要翻译： 本发明涵盖的其免疫特异性地结合一种或多种RSV抗原的组合物和包含所述抗体片段新颖的抗体和片段。 本发明包括在人类中预防呼吸道合胞病毒（RSV）感染的方法，包括给予所述人的预防有效量的一种或多种抗体或其片段也免疫特异性地结合一种或多种RSV抗原，worin的某些血清滴度 所述抗体或抗体片段在所述的人类受试者的实现。; 因此，本发明包括用于治疗或改善与RSV感染在人类相关的症状，包括给予所述人的治疗有效量的一种或多种抗体或其片段也免疫特异性地结合一种或多种RSV抗原，worin一个的某些方法 所述抗体或抗体片段的血清滴度在所述人受试者达到。 本发明还包括组合物，包含抗体或其片段免疫特异性并结合到SRV抗原，以及使用所述组合物的方法检测或诊断RSV感染。

公开(公告)号：EP2289550A2

公开(公告)日：2011-03-02

申请号：EP10007381.6

申请日：2001-01-26

申请人： MedImmune, LLC

发明人： Young, James F. ,  Johnson, Leslie S. ,  Huse, William D. ,  Wu, Herren ,  Watkins, Jeffrey D. ,  Koenig, Scott

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： Ultra high affinity antibodies with binding affinities in the range of 10 10 M -1 , and even 10 11 M -1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

摘要翻译： 公开了具有10 10 M -1，甚至10 11 M -1范围内的结合亲和力的超高亲和力抗体。 这样的抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有衍生自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们预防和/或治疗疾病，特别是病毒诱导的疾病的方法。