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1.发明公开ANTIBODIES BINDING TO THE F PROTEIN OF A RESPIRATORY SYNCYTIAL VIRUS (RSV) 审中-公开抗体与呼吸道合胞病毒（RSV）的F蛋白结合
公开(公告)号：EP2341074A1
公开(公告)日：2011-07-06
申请号：EP10010677.2
申请日：2001-03-01
发明人： Young, James F. , Koenig, Scott , Johnson, Leslie S. , Huse, William D. , Wu, Herren , Watkins, Jeffry D.
IPC分类号： C07K16/00 , C07K16/10 , A61K39/395 , A61P31/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K16/00 , C07K2317/567
摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for production of high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
摘要翻译： 公开了具有高动力学结合速率常数和任选的高亲和力的高效价抗体，包括其免疫活性片段，以及用于产生此类抗体的方法。 本文公开的高效价抗体是中和或非中和类型，并且对由微生物，特别是病毒显示的抗原以及存在于癌细胞和各种类型的毒素上的抗原性位点以及毒素产物具有特异性。 还描述了生产高效中和抗体和增加现有中和抗体的效力的方法。 公开了使用所述抗体预防和/或治疗疾病，特别是由病毒诱发或引起的疾病的方法。
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公开(公告)号：EP2341075A1
公开(公告)日：2011-07-06
申请号：EP10010678.0
申请日：2001-03-01
发明人： Young, James F. , Koenig, Scott , Johnson, Leslie S. , Huse, William D. , Wu, Herren , Watkins, Jeffry D.
IPC分类号： C07K16/00 , C07K16/10 , A61K39/395 , A61P31/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K16/00 , C07K2317/567
摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for production of high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
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公开(公告)号：EP2316487B1
公开(公告)日：2014-06-11
申请号：EP10009620.5
申请日：2004-04-12
申请人： MedImmune, LLC
IPC分类号： A61K39/395 , C07K14/52 , G01N33/53 , C07K16/24 , C07K16/46 , A61K47/48 , A61P37/06 , A61P35/00 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P31/04 , A61P31/12 , G01N33/577 , G01N33/68 , C07K14/54
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
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4.发明公开Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 审中-公开用于预防和治疗管理/剂量的抗RSV抗体的方法
公开(公告)号：EP2338512A1
公开(公告)日：2011-06-29
申请号：EP10010675.6
申请日：2001-11-28
申请人： MedImmune, LLC
发明人： Young, James F. , Koenig, Scott , Johnson, Leslie S. , Watkins, Jeffry D. , Huse, William D. , Wu, Herren
IPC分类号： A61K39/395 , A61K39/42 , A61K39/00 , A61K39/155 , C12Q1/70
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject.; The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a SRV antigen, and methods using said compositions for detection or diagnosis a RSV infection.
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5.发明公开
公开(公告)号：EP2316487A1
公开(公告)日：2011-05-04
申请号：EP10009620.5
申请日：2004-04-12
申请人： MedImmune, LLC
IPC分类号： A61K39/395 , C07K14/52 , G01N33/53 , C07K16/24 , C07K16/46 , A61K47/48 , A61P37/06 , A61P35/00 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P31/04 , A61P31/12 , G01N33/577 , G01N33/68 , C07K14/54
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，控制和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明进一步涉及制品和包含免疫特异性结合IL-9多肽的抗体的试剂盒。
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