公开(公告)号：EP3307769B1

公开(公告)日：2020-12-02

申请号：EP16732248.6

申请日：2016-06-09

申请人： MedImmune Limited

发明人： REVELL, Jefferson, D ,  BEDNAREK, Maria, A

IPC分类号： C07K14/605 ,  A61K38/26 ,  C12Q1/37

公开(公告)号：EP3495380A1

公开(公告)日：2019-06-12

申请号：EP18182274.3

申请日：2013-12-10

申请人： MedImmune Limited

发明人： AGORAM, Balaji ,  ANTONSSON, Elise, Madeleine ,  BEDNAREK, Maria, A ,  BURMEISTER, Nicole ,  BENTHEM, Lambertus ,  FAIRMAN, David ,  FRITSCH-FREDIN, Maria ,  JACKSON, Ronald Henry ,  LOFMARK, Rasmus Jansson ,  METCALFE, Jaqueline

IPC分类号： C07K14/435

摘要： The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.

公开(公告)号：EP3468987A2

公开(公告)日：2019-04-17

申请号：EP17731089.3

申请日：2017-06-08

申请人： Medimmune Limited

发明人： BEDNAREK, Maria, A

IPC分类号： C07K14/605 ,  A61K38/26 ,  C12Q1/37

公开(公告)号：EP3865504A1

公开(公告)日：2021-08-18

申请号：EP20202888.2

申请日：2016-06-09

申请人： MedImmune Limited

发明人： REVELL, Jefferson, D ,  BEDNAREK, Maria, A

IPC分类号： C07K14/605 ,  A61K38/26 ,  C12Q1/37 ,  A61P3/00

摘要： The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. A combination of lipidation of certain amino acid residues and substituition of alpha-methyl functionalized amino acids for natural amino acids has been determined to produce protease-resistant peptides.

公开(公告)号：EP3307769A1

公开(公告)日：2018-04-18

申请号：EP16732248.6

申请日：2016-06-09

申请人： Medimmune Limited

发明人： REVELL, Jefferson, D ,  BEDNAREK, Maria, A

IPC分类号： C07K14/605 ,  A61K38/26 ,  C12Q1/37

CPC分类号： C07K14/605 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

摘要： The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. A combination of lipidation of certain amino acid residues and substitution of alpha-methyl functionalized amino acids for natural amino acids has been determined to produce protease-resistant peptides.

公开(公告)号：EP3238734A1

公开(公告)日：2017-11-01

申请号：EP17174372.7

申请日：2014-03-13

申请人： Medimmune Limited

发明人： BEDNAREK, Maria, A

IPC分类号： A61K38/00 ,  C07K14/605

CPC分类号： C07K14/605 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/26 ,  A61K47/542 ,  A61K47/60

摘要： This disclosure provides pegylated GLP-1/glucagon agonist peptides for the treatment of metabolic diseases, e . g ., obesity.

摘要翻译： 本公开提供聚乙二醇化的GLP-1 /胰高血糖素激动剂肽用于治疗代谢性疾病例如肥胖症。