公开(公告)号：EP2486941A1

公开(公告)日：2012-08-15

申请号：EP12155398.6

申请日：2007-10-01

申请人： Medarex, Inc.

发明人： Kuhne, Michelle ,  Brams, Peter ,  Tanamachi, Dawn M. ,  Korman, Alan ,  Cardarelli, Josephine M.

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K47/48

CPC分类号： C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.

公开(公告)号：EP2505058A1

公开(公告)日：2012-10-03

申请号：EP12150515.0

申请日：2007-03-30

申请人： Medarex, Inc.

发明人： Tanamachi, Dawn, M. ,  Brams, Peter ,  Black, Amelia

IPC分类号： A01K67/00 ,  A01K67/027 ,  C12P21/08 ,  A61K39/00

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/1282 ,  C07K16/24 ,  C07K16/462 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/8509

摘要： The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin constant regions of the host animal allows for generation of improved antibodies in such transgenic host animals. Subsequently, the chimeric antibodies can be readily converted to fully human antibodies using recombinant DNA techniques. Thus, the invention provides compositions and methods for generating human antibodies in which chimeric antibodies raised in vivo in transgenic mice are used as intermediates and then converted to fully human antibodies in vitro.

摘要翻译： 本发明提供用于表达嵌合抗体的转基因构建体和携带这种构建体的转基因非人宿主动物，其中嵌合抗体包含人类可变区和非人转基因宿主动物的恒定区。 宿主动物的免疫球蛋白恒定区的存在允许在这些转基因宿主动物中产生改良的抗体。 随后，使用重组DNA技术可以容易地将嵌合抗体转化为完全人抗体。 因此，本发明提供了用于产生人抗体的组合物和方法，其中在转基因小鼠体内产生的嵌合抗体用作中间体，然后在体外转化为完全人抗体。