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1.发明公开HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434A2
公开(公告)日：2008-08-27
申请号：EP06840172.8
申请日：2006-12-08
申请人： MEDAREX, INC.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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2.发明授权HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434B1
公开(公告)日：2012-07-11
申请号：EP06840172.8
申请日：2006-12-08
申请人： Medarex, Inc.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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