公开(公告)号：EP1815741A1

公开(公告)日：2007-08-08

申请号：EP06100589.8

申请日：2006-01-19

申请人： Medestea Research & Production S.R.L.

发明人： Merizzi, Gianfranco ,  Soleti, Antonio

IPC分类号： A01N1/02

CPC分类号： A01N1/0226 ,  A01N1/02

摘要： The present invention relates to compositions and the use of such compositions in the formulation of preservation solutions for protecting mammalian (including human) biological systems such as biotechnological preparations (including recombinant proteins), organs, tissues (including whole blood and blood derivatives such platelets and plasma) and cells (including red blood cells, pancreatic β-cells, stem cells and germ cells) from oxidative damage occurring, for example, during the different phases of transplantation and surgery. More particularly, this invention relates to a method for protecting and/or enhancing viability of mammalian biotechnological preparations/cells/tissues/organs during isolation (or harvesting), preservation (or storage), expansion (or colture), transplantation and surgery by using compositions containing effective amount of antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine.

摘要翻译： 本发明涉及组合物和这些组合物在制备用于保护哺乳动物（包括人）生物系统如生物技术制剂（包括重组蛋白），器官，组织（包括全血和血液衍生物如血小板和 血浆）和细胞（包括红细胞，胰腺2细胞，干细胞和生殖细胞）从氧化损伤发生，例如在移植和手术的不同阶段期间发生。 更具体地说，本发明涉及一种用于在分离（或收获），保存（或储存），扩张（或串联），移植和手术期间保护和/或增强哺乳动物生物技术制剂/细胞/组织/器官的活力的方法，其通过使用 含有有效量的衍生自N-哌啶的抗氧化环氧（双） - 羟胺的组合物。