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1.发明授权NON-HYDRATED GABAPENTIN POLYMORPH, PRODUCTION PROCESS AND UTILIZATION FOR PRODUCING PHARMACEUTICAL GRADE GABAPENTIN 有权非水合加巴喷丁晶型，制造工艺和使用用于生产药物加巴喷丁纯度。
公开(公告)号：EP1083164B1
公开(公告)日：2003-11-12
申请号：EP99919275.0
申请日：1999-05-10
申请人： Medichem S.A.
发明人： BOSCH LLADO Jordi , GARCIA CRUZ, Rafael , MOLINS GRAU, Elias , ONRUBIA MIGUEL, Maria del Carmen
IPC分类号： C07C229/28 , C07C211/35
CPC分类号： C07C229/28 , C07C227/42 , C07C2601/14
摘要： The non-hydrated gapapentine polymorph is obtained by desiccating by atomization or turbodrying an aqueous solution of gabapentine; the invention also relates to its use in order to obtain gabapentine appropriate for pharmaceutical use; disclosed is a method which comprises subjecting the polymorph to a crystallization process in solvents.
摘要翻译： 非水合的多晶型物gapapentine是通过雾化的干燥剂或turbodrying到wässrige加巴喷丁的溶液得到; 所以，本发明涉及其为了获得加巴喷丁适合药物用途使用; 盘游离缺失是该方法包括将多晶型物的结晶过程中溶剂的方法。
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公开(公告)号：EP1213279B1
公开(公告)日：2004-09-15
申请号：EP00945958.7
申请日：2000-07-17
申请人： Medichem S.A.
发明人： ARNALOT I AGUILAR, Carmen , BOSCH I LLADO, Jordi , CAMPS GARCIA, Pelayo , ONRUBIA MIGUEL, Maria del Carmen , SOLDEVILLA MADRID, Nuria
IPC分类号： C07C213/08 , C07C217/74
CPC分类号： C07C213/08 , C07C217/74 , C07C2601/14
摘要： Process for producing venlafaxine and/or physiologically acceptable addition salts thereof, consisting in reacting a compound having the general formula (II) wherein R is a C1-C10 alkyl group, aryl group, aralkyl group or cycloalkyl group having from 3 to 6 carbon atoms, with an organomagnesian compound having the general formula (III) wherein X is a halogen atom and, if desired, a salt of venlafaxine can be obtained by reaction with a physiologically acceptable acid.
摘要翻译： 一种制备文拉法辛和/或其生理上可接受的加成盐的方法，其通过使通式（II）的化合物反应，其中R是3至6个碳原子的C 1 -C 10烷基，芳基，芳烷基或环烷基 与通式（III）的有机镁化合物，其中X是卤素原子，如果需要，通过与生理上可接受的酸反应形成所得文拉法新的盐。
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公开(公告)号：EP1213279A1
公开(公告)日：2002-06-12
申请号：EP00945958.7
申请日：2000-07-17
申请人： Medichem S.A.
发明人： ARNALOT I AGUILAR, Carmen , BOSCH I LLADO, Jordi , CAMPS GARCIA, Pelayo , ONRUBIA MIGUEL, Maria del Carmen , SOLDEVILLA MADRID, Nuria
IPC分类号： C07C213/08 , C07C217/74
CPC分类号： C07C213/08 , C07C217/74 , C07C2601/14
摘要： A process for the preparation of venlafaxin and/or the physiologically acceptable addition salts thereof that consists of reacting a compound of general formula (II) where R is a C 1 -C 10 alkyl, aryl, aralkyl or cycloalkyl group of 3 to 6 atoms of carbon, with a organomagnesium compound of general formula (III) where X is an atom of halogen and, if desired, a salt of the thus obtained venlafaxin is formed by reaction thereof with a physiologically acceptable acid.
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4.发明公开NON-HYDRATED GABAPENTINE POLYMORPH, PRODUCTION PROCESS AND UTILIZATION FOR PRODUCING PHARMACEUTICAL GRADE GABAPENTINE 有权非水合加巴喷丁晶型，制造工艺和使用用于生产药物加巴喷丁纯度。
公开(公告)号：EP1083164A1
公开(公告)日：2001-03-14
申请号：EP99919275.0
申请日：1999-05-10
申请人： Medichem S.A.
发明人： BOSCH LLAD , Jordi , GARCIA CRUZ, Rafael , MOLINS GRAU, Elias , ONRUBIA MIGUEL, Maria del Carmen
IPC分类号： C07C229/28 , C07C211/35
CPC分类号： C07C229/28 , C07C227/42 , C07C2601/14
摘要： The non-hydrated gapapentine polymorph is obtained by desiccating by atomization or turbodrying an aqueous solution of gabapentine; the invention also relates to its use in order to obtain gabapentine appropriate for pharmaceutical use; disclosed is a method which comprises subjecting the polymorph to a crystallization process in solvents.
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