公开(公告)号：EP4101457A1

公开(公告)日：2022-12-14

申请号：EP22160157.8

申请日：2014-09-02

申请人： MedImmune Limited

发明人： JIN, Hong ,  CARROLL, Danielle ,  MCCOURT, Matthew ,  CHENG, Xing ,  GALINSKI, Mark

IPC分类号： A61K35/76 ,  C07K14/535 ,  A61P35/00 ,  A61P35/02 ,  C12N15/86 ,  C12N7/00 ,  C07K14/005 ,  A61K35/768

摘要： The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.

公开(公告)号：EP3041490B1

公开(公告)日：2018-11-14

申请号：EP14761317.8

申请日：2014-09-02

申请人： Medimmune Limited

发明人： CHENG, Xing ,  CARROLL, Danielle ,  MCCOURT, Matthew ,  GALINSKI, Mark ,  JIN, Hong

IPC分类号： A61K35/76 ,  A61K35/768 ,  C07K14/005 ,  C07K14/535 ,  C12N15/86 ,  C12N7/00

CPC分类号： C12N7/00 ,  A61K35/768 ,  C07K14/005 ,  C07K14/535 ,  C12N15/86 ,  C12N2710/16122 ,  C12N2710/16143 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18133 ,  C12N2760/18143

摘要： The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.

公开(公告)号：EP3041490A1

公开(公告)日：2016-07-13

申请号：EP14761317.8

申请日：2014-09-02

申请人： Medimmune Limited

发明人： CHENG, Xing ,  CARROLL, Danielle ,  MCCOURT, Matthew ,  GALINSKI, Mark ,  JIN, Hong

IPC分类号： A61K35/76 ,  C07K14/535 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K35/768 ,  C07K14/005 ,  C07K14/535 ,  C12N15/86 ,  C12N2710/16122 ,  C12N2710/16143 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18133 ,  C12N2760/18143

摘要： The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.

摘要翻译： 本发明提供了用于诱导在人受试者中肿瘤的消退的方法，该方法利用新城疫病毒（NDV）的具有修饰的F蛋白切割位点的修饰的中等毒力株，所有这些是不致病的家禽（轻型），但展品溶瘤属性 ， 盘方法游离缺失提供安全，有效和可靠的手段以诱导肿瘤的消退在需要其的个体。 这些方法克服了使用病毒致病菌株为人类治疗的缺点。