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公开(公告)号：EP2987856B1
公开(公告)日：2018-07-25
申请号：EP15162322.0
申请日：2010-02-05
IPC分类号： C12N7/00 , A61K35/76 , C07K14/125 , C07K14/11
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.
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2.发明授权
公开(公告)号：EP2327764B1
公开(公告)日：2011-12-28
申请号：EP09075536.4
申请日：2009-11-30
CPC分类号： C12N7/00 , A61K35/768 , A61K45/06 , C12N2760/18121 , C12N2760/18132
摘要： A new clone of Newcastle disease virus is described which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases.
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公开(公告)号：EP2237790A1
公开(公告)日：2010-10-13
申请号：EP09704993.6
申请日：2009-01-20
发明人： BEIER, Rudolf , PÜHLER, Florian
IPC分类号： A61K35/76
CPC分类号： A61K35/768 , A61K38/00 , A61K48/00 , C07K14/56 , C07K14/565 , C12N7/00 , C12N15/86 , C12N2760/18132 , C12N2760/18143 , C12N2760/18161 , A61K2300/00
摘要： The invention refers to a recombinant oncolytic RNA Newcastle Disease Virus for the treatment of a proliferative disease, comprising at least one transgene coding for an avian cytokine, wherein the recombinant oncolytic RNA Newcastle Disease Virus is obtainable from a velogenic or mesogenic oncolytic RNA Newcastle Disease Virus. Virus-mediated expression of the cytokine in the natural host cells leads to a reduced pathogenicity of the virus for avian species. Furthermore the virus genome can encode binding proteins, prodrug-converting enzymes or/and proteases. The selective expression of these molecules in virus-infected tumor cells increases the anti-tumor effect of the virus.
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4.发明公开Attenuated oncolytic paramyxoviruses encoding avian cytokines 审中-公开Abtschwächteonkolytische Paramyxoviren zur Kodierung von Vogel-Zytokinen
公开(公告)号：EP2085092A1
公开(公告)日：2009-08-05
申请号：EP08001643.9
申请日：2008-01-29
发明人： Pühler, Florian , Beier, Rudolf
IPC分类号： A61K35/76
CPC分类号： A61K35/768 , A61K38/00 , A61K48/00 , C07K14/56 , C07K14/565 , C12N7/00 , C12N15/86 , C12N2760/18132 , C12N2760/18143 , C12N2760/18161 , A61K2300/00
摘要： The invention refers to a recombinant oncolytic RNA Newcastle Disease Virus for the treatment of a proliferative disease, comprising at least one transgene coding for an avian cytokine, wherein the recombinant oncolytic RNA Newcastle Disease Virus is obtainable from a velogenic or mesogenic oncolytic RNA Newcastle Disease Virus. Virus-mediated expression of the cytokine in the natural host cells leads to a reduced pathogenicity of the virus for avian species. Furthermore the virus genome can encode binding proteins, prodrug-converting enzymes or/and proteases. The selective expression of these molecules in virus-infected tumor cells increases the anti-tumor effect of the virus.
摘要翻译： 本发明涉及用于治疗增殖性疾病的重组溶瘤性RNA新城疫病毒，其包含编码禽类细胞因子的至少一种转基因，其中所述重组溶瘤性RNA新城疫病毒可从慢性或溶媒性新城疫病毒 。 细胞因子在天然宿主细胞中的病毒介导的表达导致病毒对禽类物种的致病性降低。 此外，病毒基因组可编码结合蛋白，前药转化酶或/和蛋白酶。 这些分子在病毒感染的肿瘤细胞中的选择性表达增加了病毒的抗肿瘤作用。
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公开(公告)号：EP1032269B1
公开(公告)日：2007-08-29
申请号：EP98949797.9
申请日：1998-10-09
发明人： ROBERTS, Michael, S. , LORENCE, Robert, M. , GROENE, William, S. , RABIN, Harvey , VON BORSTEL, Reid, W.
CPC分类号： C12N7/00 , A61K35/768 , A61K38/21 , A61K39/42 , C12N2760/18132 , C12N2760/18151 , G01N33/5011 , G01N2500/10 , G01N2800/7028 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumours. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
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公开(公告)号：EP1812026A2
公开(公告)日：2007-08-01
申请号：EP05818947.3
申请日：2005-11-10
IPC分类号： A61K35/76 , C07K14/115
CPC分类号： C07K14/005 , A01K67/0271 , A01K2267/0331 , A61K8/34 , A61K8/35 , A61K8/37 , A61K8/4953 , A61K8/922 , A61K8/97 , A61K8/99 , A61K35/768 , A61K38/1709 , A61K38/2013 , A61K38/47 , A61Q19/08 , C07K2319/33 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , A61K2300/00
摘要： The goal of the invention is to increase the therapeutical activity of oncolytic NDV. This issue is solved by a Newcastle Disease Virus comprising a recombinant nucleic acid, wherein the nucleic acid codes for a binding protein that has a therapeutic activity when expressed by the virus-infected tumor cell. Binding proteins belong to the following group: A natural ligand or a genetically modified ligand, a recombinant soluble domain of a natural receptor or a modified version of it, a peptide-ligand, an antibody molecule and derivatives thereof or antibody-like molecules like ankyrin repeat molecules or derivatives thereof.
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公开(公告)号：EP1578451A2
公开(公告)日：2005-09-28
申请号：EP03781712.9
申请日：2003-11-03
发明人： LORENCE, Robert, M. , MAJOR, Pierre
IPC分类号： A61K48/00
CPC分类号： A61K35/768 , C12N2760/18132
摘要： A negative-stranded RNA virus is used to treat a mammalian subject having a carcinoid tumor.
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公开(公告)号：EP2968525A1
公开(公告)日：2016-01-20
申请号：EP14774247.2
申请日：2014-03-04
CPC分类号： A61K35/768 , A61K39/3955 , A61K2039/505 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K2317/76 , C12N7/00 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18133 , C12N2760/18143
摘要： Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
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公开(公告)号：EP1744780A4
公开(公告)日：2009-08-05
申请号：EP05779961
申请日：2005-04-26
IPC分类号： A61K39/385 , A61K31/4745 , A61K35/76 , A61K39/12 , A61K48/00
CPC分类号： A61K35/768 , A61K31/4745 , A61K39/39558 , A61K45/06 , C12N2760/18132 , A61K2300/00
摘要： Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.
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公开(公告)号：EP1605763A4
公开(公告)日：2008-07-30
申请号：EP04775817
申请日：2004-03-02
IPC分类号： A01N63/00 , A61K20060101 , A61K35/76 , A61K39/17
CPC分类号： A61K35/768 , C12N2760/18132
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