公开(公告)号：EP3804736A1

公开(公告)日：2021-04-14

申请号：EP19815851.1

申请日：2019-06-05

申请人： Medipost Co., Ltd.

发明人： YANG, Yun Sun ,  OH, Wonil ,  CHOI, Soo Jin ,  KWAK, Jihye ,  KIM, Dong Hyon ,  LIM, Hoon

IPC分类号： A61K35/51 ,  A61P19/02 ,  A61P17/00 ,  A61P11/06

摘要： The present invention relates to a pharmaceutical composition comprising HLA-A2-expressing mesenchymal stem cells as an effective ingredient for prevention or treatment of inflammatory disease. According to the present invention, the mesenchymal stem cells expressing HLA-A2 on the surface thereof inhibit the secretion of the inflammatory cytokine TNF-a and increase the expression of the anti-inflammatory markers CD163 and Arg-1, so that the pharmaceutical composition comprising the mesenchymal stem cells as an effective ingredient can be advantageously used for suppressing inflammation or treating inflammatory diseases.