公开(公告)号：EP3329775A1

公开(公告)日：2018-06-06

申请号：EP18153287.0

申请日：2011-02-24

申请人： Medivation Prostate Therapeutics LLC

发明人： THOMPSON, Andrew ,  LAMBERSON, Carol ,  GREENFIELD, Scott ,  JAIN, Rajendra Parasmal ,  ANGELAUD, Remy

IPC分类号： A01N43/50 ,  A61K31/415 ,  C07D233/86 ,  C07D235/02 ,  C07C237/30

CPC分类号： C07D233/86 ,  C07C231/12 ,  C07C237/30 ,  C07D235/02

摘要： Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds, such as compounds of the formula:

wherein X, Y 1 , Y 2 , R 1 , and R 2 are as defined herein. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.