公开(公告)号：EP2084175A1

公开(公告)日：2009-08-05

申请号：EP07820934.3

申请日：2007-10-04

申请人： Medivir AB

发明人： JOHANSSON, Nils-Gunnar ,  KALAYANOV, Genadiy ,  MARTIN, Joseph Armstrong ,  SMITH, David Bernard ,  WINQVIST, Anna

IPC分类号： C07H19/073 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07H19/073 ,  A61K31/513 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-4hydroxy-5-hydroxymethyl-3-methyl-tetrahyclrofuran-2- yl)-1 H-pyrimidin-2-one(22) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

公开(公告)号：EP2084175B1

公开(公告)日：2010-12-29

申请号：EP07820934.3

申请日：2007-10-04

申请人： Medivir AB

发明人： JOHANSSON, Nils-Gunnar ,  KALAYANOV, Genadiy ,  MARTIN, Joseph Armstrong ,  SMITH, David Bernard ,  WINQVIST, Anna

IPC分类号： C07H19/073 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07H19/073 ,  A61K31/513 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-4hydroxy-5-hydroxymethyl-3-methyl-tetrahyclrofuran-2- yl)-1 H-pyrimidin-2-one(22) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.