专利检索 ap:("Medpacto Inc.") AND inv:"KIM, Hye Nan" 第 1 页

1.

发明公开
MODIFIED DKK2 PROTEIN, NUCLEIC ACID ENCODING THE SAME, PREPARATION METHOD THEREOF, AND USE THEREOF 审中-公开
标题翻译：修饰的DKK2蛋白，编码该核酸的核酸及其制备方法及其用途

公开(公告)号：EP3253781A1

公开(公告)日：2017-12-13

申请号：EP16746839.6

申请日：2016-02-03

申请人： Medpacto Inc.

发明人： HA, Il Ho , YOO, Seok Ho , KIM, Hye Nan , KIM, Yeung Chul , LIM, Ju Ry

IPC分类号： C07K14/47 , C12N15/63 , A61K38/17

CPC分类号： C07K14/47 , A61K38/00 , C07K2319/21 , C07K2319/30

摘要： Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified DKK2 protein having an additional glycosyl group or improved binding affinity for a substrate LRP6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.