公开(公告)号：EP3813830A1

公开(公告)日：2021-05-05

申请号：EP19824936.9

申请日：2019-06-27

申请人： Medpacto Inc.

发明人： OCK, Chan-young ,  KIM, Seong Jin

IPC分类号： A61K31/444 ,  A61K39/395 ,  A61P35/00 ,  C12Q1/6886

公开(公告)号：EP3702784A1

公开(公告)日：2020-09-02

申请号：EP18871731.8

申请日：2018-10-24

申请人： Advanced Institutes of Convergence Technology ,  Medpacto Inc.

发明人： KIM, Seong Jin ,  YANG, Kyung Min

IPC分类号： G01N33/574 ,  G01N33/68

摘要： Provided are a method of diagnosing cancer, the method including bringing a sample isolated from an individual into contact with an antibody, a polypeptide or a combination thereof, which specifically binds to a BAG2 polypeptide or a fragment thereof; measuring the presence or level of BAG2 in the sample from a complex formed by coming into contact with the antibody, the polypeptide, or the combination thereof, which specifically binds to the BAG2 polypeptide or the fragment thereof; and comparing the presence or level of BAG2 measured from the sample with a BAG2 level measured from a control group, and a kit for diagnosing cancer.

公开(公告)号：EP3236961B1

公开(公告)日：2020-07-08

申请号：EP16776857.1

申请日：2016-04-06

申请人： Medpacto Inc.

发明人： HA, Il Ho ,  KIM, Seong Jin

IPC分类号： A61K39/395 ,  A61K31/444 ,  A61K45/06 ,  A61P35/00 ,  A61K39/00 ,  C07K16/28

公开(公告)号：EP3253781A1

公开(公告)日：2017-12-13

申请号：EP16746839.6

申请日：2016-02-03

申请人： Medpacto Inc.

发明人： HA, Il Ho ,  YOO, Seok Ho ,  KIM, Hye Nan ,  KIM, Yeung Chul ,  LIM, Ju Ry

IPC分类号： C07K14/47 ,  C12N15/63 ,  A61K38/17

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/21 ,  C07K2319/30

摘要： Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified DKK2 protein having an additional glycosyl group or improved binding affinity for a substrate LRP6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.

公开(公告)号：EP3236961A4

公开(公告)日：2018-07-11

申请号：EP16776857

申请日：2016-04-06

申请人： MEDPACTO INC

发明人： HA IL HO

IPC分类号： A61K31/444 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/454 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC分类号： A61K31/444 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/76 ,  A61K2300/00

摘要： Provided are a pharmaceutical composition for preventing or treating cancer and a method of preventing or treating cancer using the same. Cancer may be effectively prevented or treated using the pharmaceutical composition and method.

公开(公告)号：EP3253781A4

公开(公告)日：2018-06-20

申请号：EP16746839

申请日：2016-02-03

申请人： MEDPACTO INC

发明人： HA IL HO ,  YOO SEOK HO ,  KIM HYE NAN ,  KIM YEUNG CHUL ,  LIM JU RY

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/17 ,  C12N15/63

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/21 ,  C07K2319/30

摘要： Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified DKK2 protein having an additional glycosyl group or improved binding affinity for a substrate LRP6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.

公开(公告)号：EP3253386A4

公开(公告)日：2018-06-20

申请号：EP16746769

申请日：2016-01-21

申请人： MEDPACTO INC

发明人： HA IL HO ,  NAKA KAZUHITO ,  LEE LEE YOUNG

IPC分类号： A61K31/4439 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/437 ,  A61P35/02 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

CPC分类号： A61K31/4196 ,  A61K31/03 ,  A61K31/4439 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

摘要： Provided are a pharmaceutical composition for preventing or treating chronic myeloid leukemia and a method of preventing or treating chronic myeloid leukemia using the same, thereby being effectively applied to the prevention or treatment of chronic myeloid leukemia.

公开(公告)号：EP3253386A1

公开(公告)日：2017-12-13

申请号：EP16746769.5

申请日：2016-01-21

申请人： Medpacto Inc.

发明人： HA, Il Ho ,  NAKA, Kazuhito ,  LEE, Lee Young

IPC分类号： A61K31/4439 ,  A61K31/437 ,  A61K31/4178 ,  A61K31/4196 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  A61P35/02

CPC分类号： A61K31/4196 ,  A61K31/03 ,  A61K31/4439 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

摘要： Provided are a pharmaceutical composition for preventing or treating chronic myeloid leukemia and a method of preventing or treating chronic myeloid leukemia using the same, thereby being effectively applied to the prevention or treatment of chronic myeloid leukemia.

公开(公告)号：EP4349358A1

公开(公告)日：2024-04-10

申请号：EP22816502.3

申请日：2022-06-03

申请人： Medpacto, Inc. ,  Kim, Seong Jin

发明人： PARK, Su Jin ,  HEO, Jin Sun ,  HONG, Eun Ji ,  AN, Hae In ,  KIM, Min Woo ,  KIM, Seong Jin

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K47/68 ,  A61P19/08 ,  A61P3/04 ,  A61P35/00 ,  C12Q1/6883 ,  C12Q1/6886 ,  G01N33/68 ,  G01N33/50

摘要： The present invention relates to a composition for preventing or treating a bone disease, obesity or an obesity-mediated metabolic disease, cancer, or cancer metastasis, and a method of screening a drug for treating the diseases, which includes an inhibitor of transmembrane 4 L six family member 19 (TM4SF19) expression or activity.

公开(公告)号：EP3938788A1

公开(公告)日：2022-01-19

申请号：EP20755277.9

申请日：2020-02-12

申请人： Medpacto, Inc. ,  Yonsei University Medical College, Gangnam Severance Hospital, Department of Surgery ,  Sungkyunkwan University, Department of Biological Sciences

发明人： KIM, Seong Jin ,  YANG, Kyung-Min ,  JEONG, Joon ,  AHN, Sung Gwe ,  PARK, Seok Hee ,  KANG, Dong Woo

IPC分类号： G01N33/574 ,  G01N33/68 ,  G01N33/577 ,  C07K16/18