公开(公告)号：EP3981769A1

公开(公告)日：2022-04-13

申请号：EP20817895.4

申请日：2020-06-05

申请人： GUANGZHOU JOYO PHARMATECH CO., LTD ,  Medshine Discovery Inc.

发明人： QIAN, Wenyuan ,  WEI, Changqing ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P29/00 ,  A61K31/519

摘要： The present invention relates to a pyrrolopyrimidine compound used as a JAK inhibitor, and the use thereof in the preparation of a drug for treating a JAK1- and/or JAK2-associated disease, and in specifically relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3640250A1

公开(公告)日：2020-04-22

申请号：EP18818915.3

申请日：2018-06-13

申请人： Medshine Discovery Inc.

发明人： LIAO, Yonggang ,  LIU, Chaonan ,  WEI, Changqing ,  WU, Hao ,  CHEN, Shuhui

IPC分类号： C07D417/14 ,  A61K31/501 ,  A61K31/4439 ,  A61P35/00

摘要： A compound as a GLS1 inhibitor as represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4067351A1

公开(公告)日：2022-10-05

申请号：EP20894671.5

申请日：2020-11-27

申请人： Medshine Discovery Inc.

发明人： LIAO, Yonggang ,  QIAN, Wenyuan ,  WEI, Changqing ,  XIAO, Yao ,  XI, Zhengying ,  ZHANG, Chen ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  A61K31/4985 ,  A61K31/415 ,  A61P35/00

摘要： Disclosed are a diazaindole derivative as shown in formula I and the use thereof in the preparation of a drug for treating Chk1-related diseases.

公开(公告)号：EP4166541A1

公开(公告)日：2023-04-19

申请号：EP21820982.3

申请日：2021-06-07

申请人： Medshine Discovery Inc.

发明人： QIAN, Wenyuan ,  LIAO, Yonggang ,  WEI, Changqing ,  XI, Zhengying ,  XIAO, Yao ,  CHEN, Shuhui

IPC分类号： C07D213/71 ,  C07D307/64 ,  C07D231/18 ,  C07D333/34 ,  C07D263/46 ,  C07D277/36 ,  A61K31/175

摘要： Disclosed in the present invention is a series of dimethylsulfoximine derivatives, and specifically disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3868758A1

公开(公告)日：2021-08-25

申请号：EP19874268.6

申请日：2019-10-15

申请人： Medshine Discovery Inc.

发明人： LIAO, Yonggang ,  LIN, Jun ,  LIU, Chaonan ,  WEI, Changqing ,  QIAN, Wenyuan ,  ZHANG, Chen ,  GONG, Zhen ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D417/14 ,  A61K31/433 ,  A61P35/00

摘要： Disclosed is to a thiadiazole derivative and the uses thereof in preparing a drug for treating GLS1-associated diseases. Specifically disclosed is a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof.