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公开(公告)号：EP3981769A1
公开(公告)日：2022-04-13
申请号：EP20817895.4
申请日：2020-06-05
发明人： QIAN, Wenyuan , WEI, Changqing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D487/04 , C07D519/00 , A61P29/00 , A61K31/519
摘要： The present invention relates to a pyrrolopyrimidine compound used as a JAK inhibitor, and the use thereof in the preparation of a drug for treating a JAK1- and/or JAK2-associated disease, and in specifically relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4129997A1
公开(公告)日：2023-02-08
申请号：EP21781242.9
申请日：2021-04-06
发明人： CHEN, Shuhui , CHEN, Kevin X , ZHOU, Kai , JIANG, Wen , HU, Guoping , LI, Jian
IPC分类号： C07D403/14 , C07D413/14 , C07D498/22 , A61K31/551 , A61K31/553 , A61P35/00
摘要： Disclosed is a class of octahydropyrazinodiazanaphthyridine dione compounds, and specifically disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3712157A1
公开(公告)日：2020-09-23
申请号：EP18872475.1
申请日：2018-11-02
发明人： CHEN, Kevin X , CHEN, Zhaoguo , ZHANG, Li , YU, Yanxin , ZHOU, Kai , HU, Boyu , WANG, Xiaofei , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D519/00 , C07D471/04 , A61K31/5386 , A61K31/5383 , A61K31/5377 , A61P35/00 , A61P35/02
摘要： Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors.
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公开(公告)号：EP3889133A1
公开(公告)日：2021-10-06
申请号：EP19900858.2
申请日：2019-12-17
发明人： DUAN, Shuwen , LU, Jianyu , HU, Lihong , DING, Charles Z. , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D209/08 , C07D221/02 , A61P35/00
摘要： Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.
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公开(公告)号：EP3470409A1
公开(公告)日：2019-04-17
申请号：EP17812617.3
申请日：2017-06-08
发明人： SUN, Fei , WU, Lifang , DING, Charles Z. , HU, Guoping , LI, Jian , CHEN, Shuhui , LU, Jianyu
IPC分类号： C07D401/14 , C07D471/04 , A61K31/4439 , A61K31/4155 , A61P35/00
摘要： A benzotriazole-derived α and β-unsaturated amide compound used as TGF-βR1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).
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公开(公告)号：EP3741756A1
公开(公告)日：2020-11-25
申请号：EP19740933.7
申请日：2019-01-18
发明人： CAI, Yaxian , XU, Zhaobing , YANG, Hailong , HAN, Shiqi , HU, Guoping , HU, Lihong , DING, Charles Z. , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
摘要： Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3502099A1
公开(公告)日：2019-06-26
申请号：EP17842893.4
申请日：2017-08-22
发明人： LUO, Yunfu , YANG, Chundao , LEI, Maoyi , SUN, Lanbao , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D235/26 , C07D263/58 , A61K31/4184 , A61K31/423 , A61P29/00 , A61P37/00
摘要： Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4273137A1
公开(公告)日：2023-11-08
申请号：EP21914669.3
申请日：2021-12-30
发明人： CHEN, Kevin X , ZHANG, Li , GUI, Houze , ZHANG, Haoyu , ZHANG, Huiyu , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D401/06 , C07D401/02 , C07D403/02 , C07D403/06 , A61K31/454 , A61P13/12
摘要： A series of piperidine-substituted benzoic acid compounds and the use thereof, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4063371A1
公开(公告)日：2022-09-28
申请号：EP20889371.9
申请日：2020-11-20
发明人： CHEN, Kevin X , XIA, Shanghua , CHEN, Zhaoguo , GUO, Zuhao , YU, Yanxin , ZHOU, Kai , HU, Boyu , ZHANG, Li , JIANG, Fen , WANG, Jingjing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D491/20 , A61K31/519 , A61K31/496 , A61P35/00 , A61P35/02
摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.
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公开(公告)号：EP4006029A1
公开(公告)日：2022-06-01
申请号：EP20844870.4
申请日：2020-07-23
发明人： CAI, Yaxian , YAN, Xiaobing , CAI, Zhe , HU, Guoping , DING, Charles Z. , CHEN, Kevin X , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/18 , C07D487/18 , A61K31/439 , A61P9/10 , A61P7/02
摘要： Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.
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