公开(公告)号：EP3498715A1

公开(公告)日：2019-06-19

申请号：EP17838686.8

申请日：2017-08-08

申请人： Medshine Discovery Inc.

发明人： XIONG, Jian ,  WANG, Jingjing ,  WU, Wentao ,  TAN, Haizhong ,  PENG, Xuanjia ,  ZHANG, Yang ,  CHEN, Kevin X ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P31/22

摘要： Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.

公开(公告)号：EP4286378A1

公开(公告)日：2023-12-06

申请号：EP22745316.4

申请日：2022-01-27

申请人： Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  LI, Zhixiang ,  ZHU, Wenyuan ,  YANG, Ping ,  LI, Qiu ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D403/14 ,  C07D403/04 ,  C07D491/052 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

摘要： The present application relates to a pyrimidopyran compound, and specifically discloses a compound as represented by formula (III), and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4144750A1

公开(公告)日：2023-03-08

申请号：EP21796159.8

申请日：2021-04-30

申请人： Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  LI, Zhixiang ,  ZHU, Wenyuan ,  QIN, Jian ,  CHEN, Shuhui

IPC分类号： C07K5/107 ,  A61K38/07 ,  A61P43/00 ,  A61P25/04 ,  A61P17/04

摘要： The use of a phenylpropionamide compound in the preparation of a drug for treating diseases associated with pain and pruritus. Specifically, the present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4293027A1

公开(公告)日：2023-12-20

申请号：EP22752307.3

申请日：2022-02-09

申请人： Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  GENG, Kaijun ,  XU, Yangyang ,  LI, Zhixiang ,  CHEN, Shuhui

IPC分类号： C07D519/00 ,  A61K31/55 ,  A61K31/439 ,  A61P35/00

摘要： Provided are pyrimidine aromatic ring compounds. Specifically provided is a compound as represented by formula (II) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4289852A1

公开(公告)日：2023-12-13

申请号：EP22749004.2

申请日：2022-01-26

申请人： Medshine Discovery Inc.

发明人： XU, Yangyang ,  WU, Wentao ,  TAN, Haizhong ,  ZAHNG, Dongkai ,  SUN, Jikui ,  ZHANG, Yang ,  CHEN, Shuhui

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P35/00

摘要： Provided are a series of 5,6-dihydrothieno[3,4-h]quinazoline compounds as represented by formula (P) and pharmaceutically acceptable salts thereof, and the use of the compounds or pharmaceutically acceptable salts thereof in the preparation of solid tumor drugs, such as solid tumor drugs associated with selective PLK1 inhibitors.

公开(公告)号：EP4059935A1

公开(公告)日：2022-09-21

申请号：EP20887944.5

申请日：2020-11-13

申请人： Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  GENG, Kaijun ,  LI, Qiu ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02 ,  A61P35/02

摘要： Disclosed are a pyrrolopyrimidine compound and a use thereof in preparing a medicine for diseases related to a BTK protein kinase inhibitor. Specially, disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4053114A1

公开(公告)日：2022-09-07

申请号：EP20883025.7

申请日：2020-10-30

申请人： Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. ,  Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  ZHU, Wenyuan ,  CHEN, Shuhui

IPC分类号： C07D333/70 ,  C07D333/62 ,  C07D307/84 ,  C07D307/82 ,  C07D409/04 ,  C07D495/04 ,  A61K31/381 ,  A61P19/06

摘要： A class of xanthine oxidase (XO) inhibitors, and application thereof in the preparation of drugs for treating XO-related diseases. Specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.