公开(公告)号：EP1988962A2

公开(公告)日：2008-11-12

申请号：EP07757216.2

申请日：2007-02-20

申请人： Medtronic, Inc.

发明人： SHELDON, Todd J. ,  COMBS, William J. ,  STYLOS, Lee ,  LU, Steven Ning ,  NEHLS, Robert J.

IPC分类号： A61N1/00

CPC分类号： A61N1/37 ,  A61N1/3627

摘要： An implantable medical device system and method in which the implantable device is adapted to operate in a minimum ventricular pacing mode. The device delivers cardiac pacing pulses in a first pacing mode during a normal mode of operation and upon detecting myocardial ischemia alters the first pacing mode in response to the myocardial ischemia detection.

公开(公告)号：EP1945300B1

公开(公告)日：2009-09-30

申请号：EP06817275.8

申请日：2006-10-19

申请人： MEDTRONIC, INC.

发明人： COMBS, William J. ,  LUNDSTROM, Russell L. Jr. ,  CHIRIFE, Raul

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3682

摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

公开(公告)号：EP1945300A1

公开(公告)日：2008-07-23

申请号：EP06817275.8

申请日：2006-10-19

申请人： MEDTRONIC, INC. ,  Chirife, Raul

发明人： COMBS, William J. ,  LUNDSTROM, Russell L. Jr.

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3682

摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

公开(公告)号：EP2136704A2

公开(公告)日：2009-12-30

申请号：EP08729694.3

申请日：2008-02-13

申请人： MEDTRONIC, INC.

发明人： COMBS, William J. ,  AUDET, Sarah A. ,  CARNEY, James K.

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/0402 ,  A61B5/721 ,  A61B5/7475

摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.

公开(公告)号：EP2012875A1

公开(公告)日：2009-01-14

申请号：EP07759911.6

申请日：2007-03-31

申请人： Medtronic, Inc.

发明人： STYLOS, Lee ,  SHELDON, Todd J. ,  LU, Steven Ning ,  COMBS, William J. ,  NEHLS, Robert J.

IPC分类号： A61N1/365 ,  A61N1/37 ,  A61N1/372

CPC分类号： A61N1/3702 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36557 ,  A61N1/37252

摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.