公开(公告)号：EP0939662A1

公开(公告)日：1999-09-08

申请号：EP96919421.0

申请日：1996-06-13

申请人： MEDTRONIC, INC.

发明人： DUFFIN, Edwin, G. ,  THOMPSON, David, L. ,  GOEDEKE, Steven, D. ,  HAUBRICH, Gregory, J.

IPC分类号： A61B5 ,  A61N1 ,  H04Q7 ,  H04Q9

CPC分类号： A61N1/37282 ,  A61B5/1112 ,  G06F19/00 ,  G06F19/3418

摘要： A system for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient (41). The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network (89). A system controller in the control device controls data and voice communications to and from the medical support network. The communications link may comprise a world wide satellite network, hardwired telephone network, a cellular telephone network or other personal communications system.

公开(公告)号：EP0559780A1

公开(公告)日：1993-09-15

申请号：EP92901365.0

申请日：1991-11-07

申请人： MEDTRONIC, INC.

发明人： DUFFIN, Edwin, G.

IPC分类号： A61N1

CPC分类号： A61N1/3622

摘要： Dans la présente invention, on compare les électrogrammes ventriculaires et (éventuellement) auriculaires dans le champ lointain, effectués sur un sujet supposé présenter des tachyarythmies, avec des modèles morphologiques enregistrés d'un ou de plusieurs rytmes de contrôle, afin d'établir une distinction entre les tachyarythmies normales et les tachyarythmies pathologiques. L'existence d'une salve tachycardique est déterminée au moyen d'un algorithme qui compare les électrogrammes auriculaires et ventriculaires dans le champ proche avec des seuils de fréquences de tachyarythmies et (éventuellement) avec une accélération de la fréquence, une stabilité de la fréquence et/ou des critères de fréquences élevées soutenues. En utilisant les électrogrammes dans le champ proche pour détecter des fréquences élevées, on peut obtenir des électrogrammes auriculaires dans le champ lointain en procédant à une détection entre l'une des électrodes bipolaires placées dans le veentricule et une électrode indifférente placée à distance, généralement sur le générateur d'impulsions ou en un point situé le long du cathéter conducteur mais à l'extérieur de l'oreillette. De même, on peut obtenir des électrogrammes ventriculaires dans le champ lointain en procédant à une détection entre l'une des électrodes auriculaires bipolaires et une électrode indifférente placée à distance.

公开(公告)号：EP1663388B1

公开(公告)日：2010-04-14

申请号：EP04780585.8

申请日：2004-08-10

申请人： Medtronic, Inc.

发明人： DENO, Curtis, D. ,  EULER, David E. ,  MULLIGAN, Lawrence, J. ,  DUFFIN, Edwin, G. ,  IGEL, David, A.

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/36514 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/368

公开(公告)号：EP1812109A1

公开(公告)日：2007-08-01

申请号：EP05817977.1

申请日：2005-10-28

申请人： MEDTRONIC, INC.

发明人： BENNETT, Tommy, D. ,  DUFFIN, Edwin, G. ,  TAEPKE, Robert, T., II. ,  KJELLSTROM, Barbro, M.

IPC分类号： A61N1/37 ,  A61N1/365 ,  A61B5/0205

CPC分类号： A61B5/0205 ,  A61B5/4035 ,  A61B5/7239 ,  A61N1/36535 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/36592 ,  A61N1/3702

摘要： A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.

公开(公告)号：EP1599132A2

公开(公告)日：2005-11-30

申请号：EP04712354.2

申请日：2004-02-18

申请人： Medtronic Inc.

发明人： BENNETT, Tommy, D. ,  DUFFIN, Edwin, G. ,  MULLIGAN, Lawrence, J. ,  HAMLEN, Robert, C. ,  ABO-AUDA, Wael

IPC分类号： A61B5/02 ,  A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0452

摘要： An implantable heart monitor (100) implanted in a patient's body having electrogram (EGM) sense electrodes (26) coupled with EGM sense circuitry (112) to generate sense events (S100) and a blood pressure measurement transducer (20) disposed in a heart chamber (10) and coupled with blood pressure measurement circuitry (112) operates to assess heart failure state (S144) as a function of mechanical pulsus alternans (MPA). MPA episodes are detected (S116), and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory (124, 128) associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.

公开(公告)号：EP1599132B1

公开(公告)日：2008-08-13

申请号：EP04712354.2

申请日：2004-02-18

申请人： Medtronic Inc.

发明人： BENNETT, Tommy, D. ,  DUFFIN, Edwin, G. ,  MULLIGAN, Lawrence, J. ,  HAMLEN, Robert, C. ,  ABO-AUDA, Wael

IPC分类号： A61B5/02 ,  A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0452

摘要： An implantable heart monitor (100) implanted in a patient's body having electrogram (EGM) sense electrodes (26) coupled with EGM sense circuitry (112) to generate sense events (S100) and a blood pressure measurement transducer (20) disposed in a heart chamber (10) and coupled with blood pressure measurement circuitry (112) operates to assess heart failure state (S144) as a function of mechanical pulsus alternans (MPA). MPA episodes are detected (S116), and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory (124, 128) associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.

公开(公告)号：EP1663388A1

公开(公告)日：2006-06-07

申请号：EP04780585.8

申请日：2004-08-10

申请人： MEDTRONIC, INC.

发明人： DENO, Curtis, D. ,  EULER, David E. ,  MULLIGAN, Lawrence, J. ,  DUFFIN, Edwin, G. ,  IGEL, David, A.

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/36514 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/368

摘要： A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.

公开(公告)号：EP0939662B1

公开(公告)日：2003-05-02

申请号：EP96919421.6

申请日：1996-06-13

申请人： MEDTRONIC, INC.

发明人： DUFFIN, Edwin, G. ,  THOMPSON, David, L. ,  GOEDEKE, Steven, D. ,  HAUBRICH, Gregory, J.

IPC分类号： A61N1/372

CPC分类号： A61N1/37282 ,  A61B5/1112 ,  G06F19/00 ,  G06F19/3418

摘要： A system for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient (41). The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network (89). A system controller in the control device controls data and voice communications to and from the medical support network. The communications link may comprise a world wide satellite network, hardwired telephone network, a cellular telephone network or other personal communications system.

公开(公告)号：EP0559780B1

公开(公告)日：1995-01-04

申请号：EP92901365.4

申请日：1991-11-07

申请人： MEDTRONIC, INC.

发明人： DUFFIN, Edwin, G.

IPC分类号： A61N1/368

CPC分类号： A61N1/3622

摘要： Far-field ventricular and (optionally) atrial electrograms of a suspect tachyarrhythmia are compared against stored morphologies of one or more control rhythms to allow discrimination between normal and pathologic tachyarrhythmias. The existence of a run of tachycardia is determined by an algorithm which compares the near-field atrial and ventricular electrograms against tachyarrhythmia rate thresholds and (optionally) rate acceleration, rate stability and/or sustained high rate criteria. When elevated rates are detected employing the near-field electrograms, far-field atrial electrograms are obtained by sensing between one of the bipolar electrodes in the ventricle and a remote indifferent electrode, typically on the pulse generator or at a location along the lead catheter but outside of the atrium. Similarly, far-field ventricular electrograms are obtained by sensing between one of the bipolar atrial electrodes and a remote indifferent electrode.