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公开(公告)号:EP2036917A1
公开(公告)日:2009-03-18
申请号:EP07744596.3
申请日:2007-06-01
发明人: KOBAYASHI, Yoshihiko , AKIYAMA, Yoshihisa , MURAKAMI, Takeshi , MINOWA, Nobuto , TSUSHIMA, Masaki , HIRAIWA, Yukiko , MURAKAMI, Shoichi , ABE, Mitsuhiro , SASAKI, Kazushige , HOSHIKO, Shigeru , MIYAKE, Toshiaki , TAKAHASHI, Yoshiaki , IKEDA, Daishiro
IPC分类号: C07H15/234 , A61K31/7036 , A61P31/04
CPC分类号: C07H15/234 , C07H15/224
摘要: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译: 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素,其诱导感染性疾病,特别是MRSA,并且不具有显着的肾毒性,以及生产它们的方法。 更具体地,本发明涉及由式(Ia)表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映异构体混合物,包含它们的抗微生物剂及其制备方法。
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公开(公告)号:EP2036917B1
公开(公告)日:2015-10-07
申请号:EP07744596.3
申请日:2007-06-01
发明人: KOBAYASHI, Yoshihiko , AKIYAMA, Yoshihisa , MURAKAMI, Takeshi , MINOWA, Nobuto , TSUSHIMA, Masaki , HIRAIWA, Yukiko , MURAKAMI, Shoichi , ABE, Mitsuhiro , SASAKI, Kazushige , HOSHIKO, Shigeru , MIYAKE, Toshiaki , TAKAHASHI, Yoshiaki , IKEDA, Daishiro
IPC分类号: C07H15/234 , A61K31/7036 , A61P31/04
CPC分类号: C07H15/234 , C07H15/224
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公开(公告)号:EP1941873A1
公开(公告)日:2008-07-09
申请号:EP06798267.8
申请日:2006-09-22
发明人: CHIKAUCHI, Ken , IDA, Mizuyo , ABE, Takao , HIRAIWA, Yukiko , MORINAKA, Akihiro , KUDO, Toshiaki
IPC分类号: A61K31/194 , A61K31/225 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K45/00 , A61P31/04 , A61P43/00 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/48 , C07C57/50 , C07C59/42 , C07C59/46
CPC分类号: A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要: A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
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