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1.发明公开NOVEL AMINOGLYCOSIDE ANTIBIOTIC EFFECTIVE AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) 审中-公开不含氨基酸 - 抗生素的麻醉剂WIRKUNG GEGEN METHICILLIN-RESISTENTES STAPHYLOCOCCUS AUREUS（MRSA）
公开(公告)号：EP1710248A1
公开(公告)日：2006-10-11
申请号：EP05703988.5
申请日：2005-01-21
发明人： MINOWA, Nobuto; , USUI, Takayuki; , AKIYAMA, Yoshihisa; , HIRAIWA, Yukiko; , YONEDA, Toshio; , HASEGAWA, Toshifumi; , MAEBASHI, Kazunori; , IDA, Takashi; , KATSUMATA, Kazuko; , OTSUKA, Keiko; , IKEDA, Daishiro
IPC分类号： C07H15/00
CPC分类号： C07H15/234 , A61K31/7036
摘要： Disclosed are compounds represented by general formula (I) or pharmacologically acceptable salts or solvates thereof having excellent antimicrobial activity against bacteria causative of severe infections such as pneumonia and septicemia, particularly against MRSA, and also antimicrobial agents comprising these compounds, and pharmaceutical compositions comprising these compounds as an active component.
摘要翻译： 公开了由通式（I）表示的化合物或其药理学上可接受的盐或溶剂合物，其对于严重感染如肺炎和败血病，特别是针对MRSA的严重感染的细菌具有优异的抗微生物活性，以及包含这些化合物的抗微生物剂，以及包含这些化合物的药物组合物 化合物作为活性组分。
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公开(公告)号：EP2036917A1
公开(公告)日：2009-03-18
申请号：EP07744596.3
申请日：2007-06-01
发明人： KOBAYASHI, Yoshihiko , AKIYAMA, Yoshihisa , MURAKAMI, Takeshi , MINOWA, Nobuto , TSUSHIMA, Masaki , HIRAIWA, Yukiko , MURAKAMI, Shoichi , ABE, Mitsuhiro , SASAKI, Kazushige , HOSHIKO, Shigeru , MIYAKE, Toshiaki , TAKAHASHI, Yoshiaki , IKEDA, Daishiro
IPC分类号： C07H15/234 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/234 , C07H15/224
摘要： This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译： 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素，其诱导感染性疾病，特别是MRSA，并且不具有显着的肾毒性，以及生产它们的方法。 更具体地，本发明涉及由式（Ia）表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映异构体混合物，包含它们的抗微生物剂及其制备方法。
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3.发明授权READ THROUGH INDUCER, AND THERAPEUTIC AGENT FOR NONSENSE-MUTATION-TYPE GENETIC DISEASES 有权ÜBERLESUNGSINDUKTOR和治疗剂，无义基因突变疾病
公开(公告)号：EP2535051B1
公开(公告)日：2016-04-20
申请号：EP11739832.1
申请日：2011-02-03
发明人： MATSUDA, Ryoichi , SHIOZUKA, Masataka , WAGATSUMA, Akira , TAKAHASHI, Yoshikazu , IKEDA, Daishiro , NONOMURA, Yoshiaki , MATSUO, Masafumi , NISHIDA, Atsushi
IPC分类号： A61K31/7036 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P7/04 , A61P9/02 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02
CPC分类号： A61K31/7036 , A61K48/00 , C07H15/234
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公开(公告)号：EP2036917B1
公开(公告)日：2015-10-07
申请号：EP07744596.3
申请日：2007-06-01
发明人： KOBAYASHI, Yoshihiko , AKIYAMA, Yoshihisa , MURAKAMI, Takeshi , MINOWA, Nobuto , TSUSHIMA, Masaki , HIRAIWA, Yukiko , MURAKAMI, Shoichi , ABE, Mitsuhiro , SASAKI, Kazushige , HOSHIKO, Shigeru , MIYAKE, Toshiaki , TAKAHASHI, Yoshiaki , IKEDA, Daishiro
IPC分类号： C07H15/234 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/234 , C07H15/224
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5.发明公开READ THROUGH INDUCER, AND THERAPEUTIC AGENT FOR NONSENSE-MUTATION-TYPE GENETIC DISEASES 有权ÜBERLESUNGSINDUKTORUND THERAPEUTISCHES MITTELFÜRERKRANKUNGEN MIT NONSENSE-GEN-MUTATIONEN
公开(公告)号：EP2535051A1
公开(公告)日：2012-12-19
申请号：EP11739832.1
申请日：2011-02-03
发明人： MATSUDA, Ryoichi , SHIOZUKA, Masataka , WAGATSUMA, Akira , TAKAHASHI, Yoshikazu , IKEDA, Daishiro , NONOMURA, Yoshiaki , MATSUO, Masafumi , NISHIDA, Atsushi
IPC分类号： A61K31/7036 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P7/04 , A61P9/02 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02
CPC分类号： A61K31/7036 , A61K48/00 , C07H15/234
摘要： A readthrough inducing agent for inducing readthrough of a premature stop codon generated by nonsense mutations, the readthrough inducing agent comprising a compound having a structure expressed by the following Structural Formula (A), and a drug for treating a genetic disease caused by nonsense mutations, the drug comprising the readthrough inducing agent.
摘要翻译： 一种用于诱导通过无义突变产生的过早终止密码子的穿透的穿透诱导剂，所述穿透诱导剂包含具有由以下结构式（A）表示的结构的化合物和用于治疗由无义突变引起的遗传疾病的药物， 所述药物包含再通过诱导剂。
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6.发明公开NOVEL COMPOUND CERAMIDASTIN, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF 审中-公开新CERAMIDASTINVERBINDUNG及其制造方法和使用
公开(公告)号：EP2330212A1
公开(公告)日：2011-06-08
申请号：EP09811402.8
申请日：2009-08-18
发明人： INOUE, Hiroyuki , KAWADA, Manabu , IKEDA, Daishiro
IPC分类号： C12P17/18 , A61K31/343 , A61K36/06 , A61P17/00 , A61P37/08 , C07D493/04 , C12N1/14 , C12N9/99
CPC分类号： C07D493/04 , A61K31/343 , A61K36/06 , C12P17/181 , C12R1/80
摘要： Disclosed are a compound having a structure expressed by the following Structural Formula (1) and a method for producing the compound including culturing a microorganism belonging to the genus Penicillium and capable of producing the compound, and recovering the compound from a culture obtained from the culturing:
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