公开(公告)号：EP3280454A1

公开(公告)日：2018-02-14

申请号：EP16718099.1

申请日：2016-04-07

申请人： Memorial Sloan Kettering Cancer Center ,  Cornell University ,  The Curators of the University of Missouri

发明人： YOO, Barney ,  QUINN, Tom ,  BRADBURY, Michelle ,  WIESNER, Ulrich ,  LEWIS, Jason ,  MA, Kai ,  CHEN, Feng

IPC分类号： A61K51/04 ,  A61K51/10 ,  A61K51/12 ,  A61P35/00

CPC分类号： A61K47/6923 ,  A61K45/06 ,  A61K49/0058 ,  A61K49/1824 ,  A61K51/0478 ,  A61K51/10 ,  A61K51/1093 ,  A61K51/1251 ,  C07K16/40 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/622

摘要： Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

公开(公告)号：EP2449379A1

公开(公告)日：2012-05-09

申请号：EP10794842.4

申请日：2010-07-02

申请人： Sloan-Kettering Institute for Cancer Research ,  Cornell University

发明人： BRADBURY, Michelle ,  WIESNER, Ulrich ,  PENATE MEDINA, Oula ,  OW, Hoosweng ,  BURNS, Andrew ,  LEWIS, Jason ,  LARSON, Steven

IPC分类号： G01N33/50

CPC分类号： A61K51/1244 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5169 ,  A61K49/0019 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0093 ,  A61K51/08 ,  A61K51/082 ,  A61K51/086 ,  A61K51/1255 ,  B82Y5/00 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/552 ,  G01N33/574 ,  G01N33/582 ,  G01N33/587 ,  G01N33/60 ,  Y10S977/773 ,  Y10S977/927

摘要： The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

公开(公告)号：EP2449379B1

公开(公告)日：2017-05-17

申请号：EP10794842.4

申请日：2010-07-02

申请人： Sloan-Kettering Institute for Cancer Research ,  Cornell University

发明人： BRADBURY, Michelle ,  WIESNER, Ulrich ,  PENATE MEDINA, Oula ,  OW, Hoosweng ,  BURNS, Andrew ,  LEWIS, Jason ,  LARSON, Steven

IPC分类号： G01N33/50

CPC分类号： A61K51/1244 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5169 ,  A61K49/0019 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0093 ,  A61K51/08 ,  A61K51/082 ,  A61K51/086 ,  A61K51/1255 ,  B82Y5/00 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/552 ,  G01N33/574 ,  G01N33/582 ,  G01N33/587 ,  G01N33/60 ,  Y10S977/773 ,  Y10S977/927

公开(公告)号：EP2968621A1

公开(公告)日：2016-01-20

申请号：EP14763612.0

申请日：2014-03-17

申请人： Sloan-Kettering Institute for Cancer Research ,  Cornell University

发明人： BRADBURY, Michelle ,  WIESNER, Ulrich ,  PENATE MEDINA, Oula ,  BURNS, Andrew ,  LEWIS, Jason ,  LARSON, Steven ,  QUINN, Tom

IPC分类号： A61K51/00 ,  A61B5/00 ,  A61K9/50 ,  G01N33/574

CPC分类号： A61K51/1244 ,  A61K49/0002 ,  A61K49/0093 ,  G01N33/54346 ,  G01N33/552 ,  G01N33/574 ,  G01N33/582 ,  G01N33/587 ,  G01N33/60

摘要： The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters, has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound, exhibits high biostability and biocompatibility, may be coated with an organic polymer, such as poly( ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. The nanoparticle may further be conjugated to a ligand. A therapeutic agent may be attached to the nanoparticle. Further, magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.

摘要翻译： 本发明提供了荧光二氧化硅基纳米颗粒，其允许对诸如癌症的疾病的精确检测，表征，监测和治疗。 纳米粒子具有一定直径范围，具有位于纳米粒子内的荧光化合物，并且具有比游离荧光化合物更高的亮度和荧光量子产率，表现出高生物稳定性和生物相容性，可以用有机聚合物如聚（乙烯 乙二醇）（PEG）。 纳米颗粒的小尺寸，二氧化硅基质和有机聚合物涂层使纳米颗粒在体内施用时的毒性最小化。 纳米颗粒可以进一步与配体缀合。 治疗剂可以附着到纳米颗粒。 此外，磁共振成像（MRI），放射性核素/放射金属或顺磁性离子可以与纳米颗粒缀合。