公开(公告)号：EP1040102A1

公开(公告)日：2000-10-04

申请号：EP98963283.1

申请日：1998-12-18

申请人： MERCK & CO., INC.

发明人： SAHOO, Soumya, P. ,  TOLMAN, Richard, L. ,  HAN, Wei ,  BERGMANN, Jeffrey ,  SANTINI, Conrad ,  LOMBARDO, Vicki, R. ,  DESAI, Ranjit ,  BOUERES, Julia, K. ,  GRATALE, Dominick, F.

IPC分类号： C07D277/34 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D263/44 ,  C07D277/34 ,  C07D417/12

摘要： Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR α, δ and/or η mediated diseases, disorders and conditions.

摘要翻译： 取代的5-芳基-2,4-噻唑烷二酮是PPAR的有效激动剂，因此可用于治疗，控制或预防糖尿病，高血糖症，高脂血症（包括高胆固醇血症和高甘油三酯血症），动脉粥样硬化，肥胖症，血管再狭窄和其他PPAR α，δ和/或η介导的疾病，病症和病症。

公开(公告)号：EP1194146A1

公开(公告)日：2002-04-10

申请号：EP00944694.9

申请日：2000-06-16

申请人： Merck & Co., Inc.

发明人： SAHOO, Soumya, P. ,  SANTINI, Conrad ,  BOUERES, Julia, K. ,  HECK, James, V. ,  METZGER, Edward ,  LOMBARDO, Victoria, K.

IPC分类号： A61K31/421 ,  A61K31/427 ,  A61K31/497 ,  C07D241/12 ,  C07D241/14 ,  C07D263/04 ,  C07D277/04

CPC分类号： C07D277/34 ,  C07D417/12

摘要： Substituted 5-aryl-2,4-thiazolidinediones or 5-aryl-2,4-oxazolidinediones that also carry a second substituent in the 5-position of the heterocyclic ring are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR α, δ and/or η mediated diseases, disorders and conditions.

公开(公告)号：EP1040102B1

公开(公告)日：2007-01-24

申请号：EP98963283.1

申请日：1998-12-18

申请人： Merck & Co., Inc.

发明人： SAHOO, Soumya, P. ,  TOLMAN, Richard, L. ,  HAN, Wei ,  BERGMANN, Jeffrey ,  SANTINI, Conrad ,  LOMBARDO, Vicki, R. ,  DESAI, Ranjit ,  BOUERES, Julia, K. ,  GRATALE, Dominick, F.

IPC分类号： C07D277/34 ,  C07D263/44 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D263/44 ,  C07D277/34 ,  C07D417/12

摘要： Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR α, δ and/or η mediated diseases, disorders and conditions.

公开(公告)号：EP1687275A1

公开(公告)日：2006-08-09

申请号：EP04811391.4

申请日：2004-11-18

申请人： Merck & Co., Inc.

发明人： LIM, Jongwon ,  BOUERES, Julia, K. ,  MUNOZ, Benito ,  PRACITTO, Richard ,  STOCK, Nicholas ,  VENKATRAMAN, Shankar

IPC分类号： C07D215/00 ,  C07D219/00 ,  A61K31/435 ,  A61K31/47

CPC分类号： C07D219/12 ,  C07D215/46

摘要： The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α2δ-1 subunit of Ca channels.

公开(公告)号：EP1194146B1

公开(公告)日：2006-07-19

申请号：EP00944694.9

申请日：2000-06-16

申请人： Merck & Co., Inc.

发明人： SAHOO, Soumya, P. ,  SANTINI, Conrad ,  BOUERES, Julia, K. ,  HECK, James, V. ,  METZGER, Edward ,  LOMBARDO, Victoria, K.

IPC分类号： C07D277/34 ,  A61K31/426 ,  A61K31/427 ,  A61K31/497 ,  C07D417/12

CPC分类号： C07D277/34 ,  C07D417/12

摘要： Substituted 5-aryl-2,4-thiazolidinediones or 5-aryl-2,4-oxazolidinediones that also carry a second substituent in the 5-position of the heterocyclic ring are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR α, δ and/or η mediated diseases, disorders and conditions.

摘要翻译： 在杂环5位还带有第二个取代基的取代的5-芳基-2,4-噻唑烷二酮或5-芳基-2,4-恶唑烷二酮是有效的PPAR激动剂，因此可用于治疗，对照 或预防糖尿病，高血糖症，高脂血症（包括高胆固醇血症和高甘油三酯血症），动脉粥样硬化，肥胖症，血管再狭窄和其他PPARα，δ和/或η介导的疾病，病症和病症。

公开(公告)号：EP1347755A2

公开(公告)日：2003-10-01

申请号：EP01997102.7

申请日：2001-10-26

申请人： Merck & Co., Inc.

发明人： SAHOO, Soumya, P. ,  KOYAMA, Hiroo ,  MILLER, Daniel, J. ,  BOUERES, Julia, K. ,  DESAI, Ranjit, C.

IPC分类号： A61K31/335 ,  C07D311/66 ,  C07D407/12 ,  C07D413/12 ,  A61P3/10

CPC分类号： C07D407/12 ,  A61K45/06 ,  C07D311/66 ,  C07D413/12

摘要： A class of benzopyrancarboxylic acid derivatives of formula I comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.

公开(公告)号：EP1324995A2

公开(公告)日：2003-07-09

申请号：EP01973277.5

申请日：2001-09-21

申请人： Merck & Co., Inc.

发明人： SAHOO, Soumya, P. ,  KOYAMA, Hiroo ,  MILLER, Daniel, J. ,  BOUERES, Julia, K. ,  DESAI, Ranjit, C.

IPC分类号： C07D311/66 ,  A61K31/353 ,  A61P3/10

CPC分类号： C07D311/66

摘要： A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.