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1.发明公开BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权杂环β-氨基化合物作为用于治疗或二肽基肽酶抑制剂 预防糖尿病
公开(公告)号：EP1490335A2
公开(公告)日：2004-12-29
申请号：EP03745557.3
申请日：2003-03-21
申请人： Merck & Co., Inc.
IPC分类号： C07D211/36 , A61K31/495
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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2.发明授权BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权杂环β-氨基化合物作为用于治疗或二肽基肽酶抑制剂 预防糖尿病
公开(公告)号：EP1490335B1
公开(公告)日：2007-09-19
申请号：EP03745557.3
申请日：2003-03-21
申请人： Merck & Co., Inc.
IPC分类号： C07D487/04 , A61K31/495 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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