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1.发明公开
公开(公告)号：EP0586513A1
公开(公告)日：1994-03-16
申请号：EP92912039.0
申请日：1992-05-05
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A. , ASHTON, Wallace, T. , CHANG, Linda, L.
IPC分类号： A61K31 , A61P9 , A61P25 , A61P27 , C07D209 , C07D249 , C07D271 , C07D285 , C07D291 , C07D401 , C07D403 , C07D405 , C07D413 , C07D417 , C07D419 , C07F9
CPC分类号： C07D413/10 , C07D249/12 , C07D417/10 , C07D419/10
摘要： Nouveaux composés de triazolinone, de triazolinethione et de triazolinimine substitués, de la formule (I), utiles en tant qu'antagonistes de l'angiotensine II.
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2.发明授权BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权杂环β-氨基化合物作为用于治疗或二肽基肽酶抑制剂 预防糖尿病
公开(公告)号：EP1490335B1
公开(公告)日：2007-09-19
申请号：EP03745557.3
申请日：2003-03-21
申请人： Merck & Co., Inc.
IPC分类号： C07D487/04 , A61K31/495 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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3.发明授权
公开(公告)号：EP1554280B1
公开(公告)日：2007-08-15
申请号：EP03759681.4
申请日：2003-10-03
申请人： Merck & Co., Inc.
IPC分类号： C07D487/04 , A61K31/4985 , A61P9/10 , A61P25/28 , A61P3/10 , A61P3/12 , A61P25/02
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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4.发明授权BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权β-氨基四氢（1,2-A）吡嗪和-TETRAHYDROTRIAZOLO（4,3-A）吡嗪ALS二肽基肽酶抑制剂对于糖尿病的治疗或预防
公开(公告)号：EP1412357B1
公开(公告)日：2006-03-22
申请号：EP02749813.8
申请日：2002-07-05
申请人： Merck & Co., Inc.
发明人： EDMONDSON, Scott, D. , FISHER, Michael, H. , KIM, Dooseop , MACCOSS, Malcolm , PARMEE, Emma, R. , WEBER, Ann, E. , XU, Jinyou
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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5.发明公开BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权β-氨基四氢吡啶甲酸（1,2-A）吡咯烷酮（4,3-A）吡嗪ALS DIPEPTIDYL PEPTIDASE INHIBITOREN ZUR BEHANDLUNG ODER PREVENTION VON DIABETES
公开(公告)号：EP1412357A1
公开(公告)日：2004-04-28
申请号：EP02749813.8
申请日：2002-07-05
申请人： Merck & Co., Inc.
发明人： EDMONDSON, Scott, D. , FISHER, Michael, H. , KIM, Dooseop , MACCOSS, Malcolm , PARMEE, Emma, R. , WEBER, Ann, E. , XU, Jinyou
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及包含二肽基肽酶-IV酶抑制剂（“DP-IV抑制剂”）的化合物的药物组合物，以及这些组合物在治疗或预防二肽基肽酶-IV酶是 涉及，如糖尿病，特别是2型糖尿病。
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6.发明公开SUBSTITUTED 1-(2H)-ISOQUINOLINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS 失效取代的1-（2H）-ISOCHINOLINONE具有酸性官能团作为血管紧张素II拮抗剂。
公开(公告)号：EP0587698A1
公开(公告)日：1994-03-23
申请号：EP92911951.0
申请日：1992-05-06
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A. , DE LASZLO, Stephen, E.
CPC分类号： C07D413/10 , C07D217/24 , C07D417/10 , C07D419/10 , C07F9/62
摘要： 1-(2H)-isoquinolinones substituées de la formule structurelle (I), qui sont des antagonistes de l'angiotensine II utiles dans le traitement de l'hypertension et de l'insuffisance cardiaque.
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7.发明公开BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权杂环β-氨基化合物作为用于治疗或二肽基肽酶抑制剂 预防糖尿病
公开(公告)号：EP1490335A2
公开(公告)日：2004-12-29
申请号：EP03745557.3
申请日：2003-03-21
申请人： Merck & Co., Inc.
IPC分类号： C07D211/36 , A61K31/495
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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公开(公告)号：EP1171122A1
公开(公告)日：2002-01-16
申请号：EP00921700.1
申请日：2000-04-05
申请人： Merck & Co., Inc.
发明人： CHAPMAN, Kevin , HALE, Jeffrey , KIM, Dooseop , LYNCH, Christopher , SHAH, Shrenik , SHANKARAN, Kothandaraman , SHEN, Dong-Ming , WILLOUGHBY, Christopher , MACCOSS, Malcolm , MILLS, Sander, G. , LOEBACH, Jennifer, L. , GUTHIKONDA, Ravindra, N.
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61P9/10 , A61P31/18
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to pyrrolidine compounds of formula (I) (wherein R?1, R2, R3, R4, R5, R6, R14¿ and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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9.发明公开SUBSTITUTED PYRIMIDINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS 失效与酸性官能团血管紧张素II拮抗剂取代嘧啶酮类。
公开(公告)号：EP0587814A1
公开(公告)日：1994-03-23
申请号：EP92917350.0
申请日：1992-04-24
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A.
IPC分类号： A61K31 , A61P9 , A61P43 , C07D473 , C07D475 , C07D487 , C07D491 , C07D495 , C07D498 , C07D513 , C07F9
CPC分类号： C07D487/04 , C07D475/02 , C07D475/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07F9/6561
摘要： De nouvelles pyrimidinones fusionnées et substituées de la formule (I) peuvent être utilisées comme antagonistes d'angiotensine II.
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10.发明授权
公开(公告)号：EP1192133B1
公开(公告)日：2006-11-02
申请号：EP00939673.0
申请日：2000-06-08
申请人： Merck & Co., Inc.
发明人： FINKE, Paul, E. , HILFIKER, Kerry, A. , MACCOSS, Malcolm , CHAPMAN, Kevin, T. , LOEBACH, Jennifer, L. , MILLS, Sander, G. , GUTHIKONDA, Ravi, N. , SHAH, Shrenik, K. , KIM, Dooseop , SHEN, Dong-Ming , OATES, Bryan
IPC分类号： C07D211/14 , C07D271/12 , C07D239/42 , C07D231/12 , C07D277/30 , C07D263/32 , A61K31/4409 , A61P37/00 , A61P31/18
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The present invention is directed to compounds of formula (I) (wherein R?1, R3, R4, R5, R6, R7, R8¿, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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