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1.发明授权
公开(公告)号：EP0322036B1
公开(公告)日：1992-06-17
申请号：EP88202882.2
申请日：1988-12-14
申请人： Merck & Co., Inc.
发明人： Burg, Richard W. , Dulaney, Eugene L. , Hensens, Otto D. , Liesch, Jerrold M. , Ondeyka, John G. , Wichmann, Carol F. , Huang, Leeyuan
IPC分类号： C07J9/00 , C07J31/00 , C07J17/00 , C12P33/00 , A61K31/575
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
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公开(公告)号：EP0157553B1
公开(公告)日：1988-06-01
申请号：EP85301983.4
申请日：1985-03-22
申请人： Merck & Co., Inc.
CPC分类号： C12R1/55 , A01N57/12 , C07F9/117 , C12P13/00 , Y10S435/898
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3.发明公开
公开(公告)号：EP0366838A1
公开(公告)日：1990-05-09
申请号：EP88310326.9
申请日：1988-11-02
申请人： Merck & Co., Inc.
发明人： Borris, Robert P. , Burg, Richard W. , Hensens, Otto D. , Huang, Leeyuan , Kelemen, Livia , Mochales, Sagrario
CPC分类号： C07J71/0005 , Y10S435/911
摘要： The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM , ATCC No. 20826.
The compounds of Formula I are inhibitors of testosterone 5α-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.摘要翻译： 式I的化合物通过GLIOCLADIUM，ATCC No. 20826的真菌的需氧发酵产生。式I化合物是睾酮5α-还原酶的抑制剂，可用于治疗和预防痤疮 ，皮脂溢，女性多毛症和良性前列腺肥大。
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公开(公告)号：EP0157553A3
公开(公告)日：1986-02-19
申请号：EP85301983
申请日：1985-03-22
申请人： MERCK & CO. INC.
CPC分类号： C12R1/55 , A01N57/12 , C07F9/117 , C12P13/00 , Y10S435/898
摘要： A series of macrolides is isolated from the fermentation broth of a novel microorganism identified as MA-5000 (ATCC 39476) which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. Based upon analytical studies, the compounds have been found to have the formula:
in which R 2 is NH 3 ⊕, R 3 is -O-PO 3 H⊖ and R I is 2-methylpropanoyl, 2-methylbutanoyl or hydrogen, or in which R 1 is 2-methylbutanoyl, R 2 is hydroxy and R 3 is -O-P0 3 H 2 . These compounds have been found to be antifungal and are used in pharmaceutical and industrial (including argricultur- al) applications.-
5.发明公开
公开(公告)号：EP0322036A1
公开(公告)日：1989-06-28
申请号：EP88202882.2
申请日：1988-12-14
申请人： Merck & Co., Inc.
发明人： Burg, Richard W. , Dulaney, Eugene L. , Hensens, Otto D. , Liesch, Jerrold M. , Ondeyka, John G. , Wichmann, Carol F. , Huang, Leeyuan
IPC分类号： C07J9/00 , C07J31/00 , C07J17/00 , C12P33/00 , A61K31/575
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of soil microorganism L-681,512 under controlled fermentation conditions.
摘要翻译： 公开了通过在受控发酵条件下培养土壤微生物L-681,512产生的天然产物的抗炎和抗变性化合物。
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6.发明公开Antifungal substances and their production and compositions containing them 失效Antifungische Substanzen und ihre Herstellung und sie enthaltende Mittel。
公开(公告)号：EP0157553A2
公开(公告)日：1985-10-09
申请号：EP85301983.4
申请日：1985-03-22
申请人： Merck & Co., Inc.
CPC分类号： C12R1/55 , A01N57/12 , C07F9/117 , C12P13/00 , Y10S435/898
摘要： A series of macrolides is isolated from the fermentation broth of a novel microorganism identified as MA-5000 (ATCC 39476) which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. Based upon analytical studies, the compounds have been found to have the formula:
in which R 2 is NH 3 ⊕, R 3 is -O-PO 3 H⊖ and R I is 2-methylpropanoyl, 2-methylbutanoyl or hydrogen, or in which R 1 is 2-methylbutanoyl, R 2 is hydroxy and R 3 is -O-P0 3 H 2 .
These compounds have been found to be antifungal and are used in pharmaceutical and industrial (including argricultur- al) applications.摘要翻译： 从鉴定为MA-5000（ATCC 39476）的新型微生物的发酵液中分离出一系列大环内酯类，其形态学分析显示为吸水链霉菌菌株。 基于分析研究，已经发现化合物具有下列通式：其中R 2是NH 3，（R 3）是-O-PO 3 H（ - ）>，其中R 1是2-甲基 - 丙酰基 ，2-甲基丁酰基或氢，或其中R1是2-甲基丁酰基，R2是羟基，R3是-O-PO3H2。 已经发现这些化合物是抗真菌剂并且用于制药和工业（包括农业）应用中。
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