-
公开(公告)号：EP0311193A2
公开(公告)日：1989-04-12
申请号：EP88202137.1
申请日：1988-09-29
申请人： Merck & Co., Inc.
发明人： Del Val, Sagrario Mochales , Fromtling, Robert A. , Schwartz, Robert E. , Giacobbe, Robert A. , Wichmann, Carol F. , Liesch, Jerrold M. , Garrity, George M.
摘要： An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
摘要翻译： 通过培养未鉴定的微生物产生的抗真菌剂是对人类病原体具有非常高的活性和非常低的哺乳动物毒性的环状脂肽。 还描述了其生产和分离。
-
公开(公告)号：EP0311193B1
公开(公告)日：1993-12-01
申请号：EP88202137.1
申请日：1988-09-29
申请人： Merck & Co., Inc.
-
公开(公告)号：EP0293131A2
公开(公告)日：1988-11-30
申请号：EP88304489.3
申请日：1988-05-18
申请人： Merck & Co., Inc.
发明人： Hensens, Otto D. , Kempf, August J. , Schwartz, Robert E. , Sykes, Ruth S. , Wichmann, Carol F. , Zimmerman, Sheldon B. , Zink, Deborah L. , Wilson, Kenneth E.
IPC分类号： C07D317/36 , A01N43/28
CPC分类号： C07D317/36 , A01N43/28
摘要： The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616. The tri-yne carbonate has antifungal activity.
摘要翻译： 本发明涉及式I的新型三烯碳酸酯。该化合物可以通过从ATCC-53614，ATCC-53615或ATCC-53616的发酵液中分离来制备。 三烯碳酸酯具有抗真菌活性。
-
公开(公告)号：EP0448301A3
公开(公告)日：1992-06-24
申请号：EP91302223.2
申请日：1991-03-15
申请人： MERCK & CO. INC.
发明人： Sesin, David F. , Liesch, Jerrold M. , Fountoulakis, Jimmy M. , Masurekar, Prakash S. , Kaplan, Louis , Wichmann, Carol F.
摘要： A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
-
5.发明公开
公开(公告)号：EP0322036A1
公开(公告)日：1989-06-28
申请号：EP88202882.2
申请日：1988-12-14
申请人： Merck & Co., Inc.
发明人： Burg, Richard W. , Dulaney, Eugene L. , Hensens, Otto D. , Liesch, Jerrold M. , Ondeyka, John G. , Wichmann, Carol F. , Huang, Leeyuan
IPC分类号： C07J9/00 , C07J31/00 , C07J17/00 , C12P33/00 , A61K31/575
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of soil microorganism L-681,512 under controlled fermentation conditions.
摘要翻译： 公开了通过在受控发酵条件下培养土壤微生物L-681,512产生的天然产物的抗炎和抗变性化合物。
-
公开(公告)号：EP0448355A3
公开(公告)日：1992-06-24
申请号：EP91302373.5
申请日：1991-03-19
申请人： MERCK & CO. INC.
发明人： Sesin, David F. , Masurekar, Prakash S. , Liesch, Jerrold M. , Kaplan, Louis , Fountoulakis, Jimmy M. , Wichmann, Carol F.
摘要： A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
-
7.发明授权
公开(公告)号：EP0322036B1
公开(公告)日：1992-06-17
申请号：EP88202882.2
申请日：1988-12-14
申请人： Merck & Co., Inc.
发明人： Burg, Richard W. , Dulaney, Eugene L. , Hensens, Otto D. , Liesch, Jerrold M. , Ondeyka, John G. , Wichmann, Carol F. , Huang, Leeyuan
IPC分类号： C07J9/00 , C07J31/00 , C07J17/00 , C12P33/00 , A61K31/575
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
-
公开(公告)号：EP0448355A2
公开(公告)日：1991-09-25
申请号：EP91302373.5
申请日：1991-03-19
申请人： MERCK & CO. INC.
发明人： Sesin, David F. , Masurekar, Prakash S. , Liesch, Jerrold M. , Kaplan, Louis , Fountoulakis, Jimmy M. , Wichmann, Carol F.
摘要： A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
摘要翻译： 描述了一种新的抗生素环脂肽及其生产方法。 该药物对人类病原体具有非常高的活性，并且具有非常低的哺乳动物毒性。
-
公开(公告)号：EP0448301A2
公开(公告)日：1991-09-25
申请号：EP91302223.2
申请日：1991-03-15
申请人： MERCK & CO. INC.
发明人： Sesin, David F. , Liesch, Jerrold M. , Fountoulakis, Jimmy M. , Masurekar, Prakash S. , Kaplan, Louis , Wichmann, Carol F.
摘要： A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
摘要翻译： 描述了一种新的抗生素环状脂肽及其生产方法。 该药剂对人类病原体的活性非常高，哺乳动物的毒性非常低。
-
公开(公告)号：EP0311193A3
公开(公告)日：1990-07-04
申请号：EP88202137.1
申请日：1988-09-29
申请人： Merck & Co., Inc.
发明人： Del Val, Sagrario Mochales , Fromtling, Robert A. , Schwartz, Robert E. , Giacobbe, Robert A. , Wichmann, Carol F. , Liesch, Jerrold M. , Garrity, George M.
摘要： An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.011 秒)
