公开(公告)号：EP1982185A2

公开(公告)日：2008-10-22

申请号：EP07716897.9

申请日：2007-01-23

申请人： Merck & Co., Inc.

发明人： BROWN, Martha, J. ,  ANDERSON, Annaliesa, S. ,  COPE, Leslie, D. ,  JANSEN, Kathrin, Ute ,  MCNEELY, Tessie ,  HARVEY, Barrett ,  DURR, Erberhard ,  ERNST, Robin

IPC分类号： G01N33/53 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/92

摘要： The present invention features antigen binding protein that bind an ORF0657n target region (SEQ ID NO: 1). ORF0657n is an S. aureus protein. ORF0657n target regions are provided by the mAb 1G3.BD4, mAb 2H2.BE11, mAb 13C7.BC1, and mAb 13G11.BF3 binding sites. In a lethal model challenge, mAb 2H2.BE11 and mAb 13C7.BC1 provided for increased survival against S. aureus infection. There was also protection demonstrated in an ex vivo model with either the IgG1 or the IgG2b form of mAb 2H2; and in a passive immunization murine indwelling catheter model using mAb 2H2.BE11.

公开(公告)号：EP1455817B1

公开(公告)日：2008-12-31

申请号：EP02790044.8

申请日：2002-12-06

申请人： Merck & Co., Inc.

发明人： JOYCE, Joseph, G ,  COOK, James, C. III ,  ABEYGUNAWARDANA, Chitrananda ,  GRIMM, Karen, M. ,  PRZYSIECKI, Craig, T. ,  HEPLER, Robert, W. ,  IP, Charlotte, C. ,  ROPER, Keith ,  XU, Qinwei ,  JANSEN, Kathrin, U. ,  KELLER, Paul, M. ,  COPE, Leslie, D.

IPC分类号： A61K39/02 ,  A61K39/085 ,  C08B37/00

CPC分类号： A61K39/085

摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly- 1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.

公开(公告)号：EP1455817A2

公开(公告)日：2004-09-15

申请号：EP02790044.8

申请日：2002-12-06

申请人： Merck & Co., Inc.

发明人： JOYCE, Joseph, G ,  COOK, James, C. III ,  ABEYGUNAWARDANA, Chitrananda ,  GRIMM, Karen, M. ,  PRZYSIECKI, Craig, T. ,  HEPLER, Robert, W. ,  IP, Charlotte, C. ,  ROPER, Keith ,  XU, Qinwei ,  JANSEN, Kathrin, U. ,  KELLER, Paul, M. ,  COPE, Leslie, D.

IPC分类号： A61K39/02 ,  A61K39/085 ,  C08B37/00

CPC分类号： A61K39/085

摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly- 1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.