公开(公告)号：EP1694654A2

公开(公告)日：2006-08-30

申请号：EP04800897.3

申请日：2004-11-05

申请人： Merck & Co., Inc.

发明人： PARK, Min, K. ,  CHAKRAVARTY, Prasun, K. ,  ZHOU, Bishan ,  GONZALEZ, Edward ,  OK, Hyun ,  PALUCKI, Brenda ,  PARSONS, William, H. ,  SISCO, Rosemary ,  FISHER, Michael, H.

IPC分类号： C07D249/10 ,  A61K31/4196 ,  A61P25/00

CPC分类号： C07D249/10 ,  C07D403/10

摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).