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1.发明公开
公开(公告)号：EP1192133A1
公开(公告)日：2002-04-03
申请号：EP00939673.0
申请日：2000-06-08
申请人： Merck & Co., Inc.
发明人： FINKE, Paul, E. , HILFIKER, Kerry, A. , MACCOSS, Malcolm , CHAPMAN, Kevin, T. , LOEBACH, Jennifer, L. , MILLS, Sander, G. , GUTHIKONDA, Ravi, N. , SHAH, Shrenik, K. , KIM, Dooseop , SHEN, Dong-Ming , OATES, Bryan
IPC分类号： C07D211/14 , C07D271/12 , C07D239/42 , C07D231/12 , C07D277/30 , C07D263/32 , A61K31/4409 , A61P37/00 , A61P31/18
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The present invention is directed to compounds of formula (I) (wherein R?1, R3, R4, R5, R6, R7, R8¿, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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2.发明授权
公开(公告)号：EP1192133B1
公开(公告)日：2006-11-02
申请号：EP00939673.0
申请日：2000-06-08
申请人： Merck & Co., Inc.
发明人： FINKE, Paul, E. , HILFIKER, Kerry, A. , MACCOSS, Malcolm , CHAPMAN, Kevin, T. , LOEBACH, Jennifer, L. , MILLS, Sander, G. , GUTHIKONDA, Ravi, N. , SHAH, Shrenik, K. , KIM, Dooseop , SHEN, Dong-Ming , OATES, Bryan
IPC分类号： C07D211/14 , C07D271/12 , C07D239/42 , C07D231/12 , C07D277/30 , C07D263/32 , A61K31/4409 , A61P37/00 , A61P31/18
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The present invention is directed to compounds of formula (I) (wherein R?1, R3, R4, R5, R6, R7, R8¿, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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