公开(公告)号：EP1685379A2

公开(公告)日：2006-08-02

申请号：EP04801804.8

申请日：2004-07-09

申请人： Merck & Co., Inc.

发明人： JACOBSON, Marlene, A. ,  WANG, Ruiping

IPC分类号： G01N1/00

CPC分类号： G01N33/502 ,  G01N33/5008 ,  G01N33/5032 ,  G01N33/5038 ,  G01N33/5041 ,  G01N33/6872 ,  G01N33/9406 ,  G01N2333/70571

摘要： The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a target cell surface protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which modulate the bioactivity of the cellular proteins. The subject assays are particularly amenable for high throughput formats and are particular useful in identifying modulators of a mammalian metabotropic glutamate receptor protein.

公开(公告)号：EP1596867A2

公开(公告)日：2005-11-23

申请号：EP04711914.4

申请日：2004-02-17

申请人： Merck & Co., Inc.

发明人： CONN, P., Jeffrey ,  JACOBSON, Marlene, A. ,  MALLORGA, Pierre, J. ,  SCOLNICK, Edward, M. ,  SUR, Cyrille

IPC分类号： A61K31/55 ,  A61K31/335

CPC分类号： A61K31/4439 ,  A61K31/00 ,  A61K31/335 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/5415 ,  A61K31/55

摘要： A muscarinic M1 receptor ectopic activator, such as a muscarinic M1 receptor allosteric potentiator or a muscarinic M1 receptor ectopic agonist is useful, alone or in combination with other antipsychotic agents, for treating or preventing psychosis, such as a schizophrenic disorder or psychosis in Alzheimer's disease or bipolar disorder, for enhancing cognition and for neuropathic pain.