公开(公告)号：EP1596867A2

公开(公告)日：2005-11-23

申请号：EP04711914.4

申请日：2004-02-17

申请人： Merck & Co., Inc.

发明人： CONN, P., Jeffrey ,  JACOBSON, Marlene, A. ,  MALLORGA, Pierre, J. ,  SCOLNICK, Edward, M. ,  SUR, Cyrille

IPC分类号： A61K31/55 ,  A61K31/335

CPC分类号： A61K31/4439 ,  A61K31/00 ,  A61K31/335 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/5415 ,  A61K31/55

摘要： A muscarinic M1 receptor ectopic activator, such as a muscarinic M1 receptor allosteric potentiator or a muscarinic M1 receptor ectopic agonist is useful, alone or in combination with other antipsychotic agents, for treating or preventing psychosis, such as a schizophrenic disorder or psychosis in Alzheimer's disease or bipolar disorder, for enhancing cognition and for neuropathic pain.

公开(公告)号：EP0786997A1

公开(公告)日：1997-08-06

申请号：EP95937615.0

申请日：1995-10-24

申请人： MERCK & CO., INC.

发明人： THOMPSON, Wayne, J. ,  SUGRUE, Michael, F. ,  RANSOM, Richard, W. ,  MALLORGA, Pierre, J. ,  BELL, Ian, M. ,  SMITH, Anthony, M.

IPC分类号： A61K31 ,  A61P27 ,  A61P43 ,  C07D401 ,  C07D403 ,  C07D471

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： Compounds, 1,3-dihydro-1-{1-[piperidin-4-yl]piperidin-4-yl}-2H-benzimidazol-2-ones and 1,3-dihydro-1-{4-amino-1-cyclohexyl}-2H-benzimidazol-2-ones and derivatives thereof, their preparation, method of use and pharmaceutical compositions are described. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).