公开(公告)号：EP1546115A2

公开(公告)日：2005-06-29

申请号：EP03759514.7

申请日：2003-09-23

申请人： Merck & Co., Inc.

发明人： KOPKA, Ihor, E. ,  LI, Bing ,  HAGMANN, William, K.

IPC分类号： C07D239/28 ,  C07D239/34 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D239/58 ,  A61K31/505 ,  A61K31/506 ,  A61P25/18 ,  A61P25/28

CPC分类号： C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D401/12 ,  C07D487/08

摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

公开(公告)号：EP2064204A1

公开(公告)日：2009-06-03

申请号：EP07837478.2

申请日：2007-08-29

申请人： Merck & Co., Inc.

发明人： OGAWA, Anthony ,  UJJAINWALLA, Feroze ,  VANDE BUNTE, Ellen, K. ,  CHU, Lin ,  ONDEYKA, Debra ,  KOPKA, Ihor ,  LI, Bing ,  OK, Hyun ,  PATEL, Minal, J. ,  XU, Jinyou ,  SISCO, Rosemary

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4427 ,  A61K31/501 ,  A61P9/10

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D417/14

摘要： The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

公开(公告)号：EP1814877A2

公开(公告)日：2007-08-08

申请号：EP05804385.2

申请日：2005-10-14

申请人： Merck & Co., Inc.

发明人： CHU, Lin ,  KOPKA, Ihor, E. ,  LI, Bing ,  OGAWA, Anthony, K. ,  UJJAINWALLA, Feroze

IPC分类号： C07D413/12 ,  C07D401/12 ,  C07D401/14 ,  C07D213/30 ,  A61K31/4439 ,  A61P9/10

CPC分类号： C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： The instant invention provides compounds of Formula (I), which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

公开(公告)号：EP1814877B1

公开(公告)日：2009-03-11

申请号：EP05804385.2

申请日：2005-10-14

申请人： Merck & Co., Inc.

发明人： CHU, Lin ,  KOPKA, Ihor, E. ,  LI, Bing ,  OGAWA, Anthony, K. ,  UJJAINWALLA, Feroze

IPC分类号： C07D413/12 ,  C07D401/12 ,  C07D401/14 ,  C07D213/30 ,  A61K31/4439 ,  A61P9/10

CPC分类号： C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： The instant invention provides compounds of Formula (I), which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

公开(公告)号：EP2013174A2

公开(公告)日：2009-01-14

申请号：EP07774859.8

申请日：2007-04-06

申请人： Merck & Co., Inc.

发明人： CHU, Lin ,  LI, Bing ,  OGAWA, Anthony, K. ,  OK, Hyun, O. ,  ONDEYKA, Debra, L. ,  PATEL, Minal ,  SISCO, Rosemary ,  UJJAINWALLA, Feroze ,  XU, Jinyou

IPC分类号： C07D213/65 ,  C07D401/04 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4412 ,  A61P29/00

CPC分类号： C07D213/65 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The instant invention provides compounds of Formula (II) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (II) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.