公开(公告)号：EP2134342A2

公开(公告)日：2009-12-23

申请号：EP08726587.2

申请日：2008-03-07

申请人： Merck & Co., Inc.

发明人： BELL, Ian, M. ,  STUMP, Craig, A. ,  SELNICK, Harold, G.

IPC分类号： A61K31/44 ,  A61K31/40

CPC分类号： C07D471/20 ,  C07D403/12 ,  C07D471/10 ,  C07D519/00

摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP2024358A1

公开(公告)日：2009-02-18

申请号：EP07776804.2

申请日：2007-05-04

申请人： Merck & Co., Inc.

发明人： WOOD, Michael, R. ,  BELL, Ian, M. ,  GALLICCHIO, Steven, N. ,  SELNICK, Harold, G. ,  STUMP, Craig, A. ,  ZARTMAN, C. Blair

IPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D519/00 ,  A61K31/403 ,  A61K31/407 ,  C07D471/20 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/438 ,  A61K31/4965 ,  A61K31/499

CPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: I (wherein variables A1, A2, A3, A4, M, N, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP1613368A2

公开(公告)日：2006-01-11

申请号：EP04719234.9

申请日：2004-03-10

申请人： Merck & Co. Inc.

发明人： BELL, Ian, M. ,  GALLICCHIO, Steven, N. ,  STUMP, Craig, A. ,  ZARTMAN, Blair, C.

IPC分类号： A61M1/00

CPC分类号： C07D233/78 ,  C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D471/10 ,  C07D513/04

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP1606286A2

公开(公告)日：2005-12-21

申请号：EP04749375.4

申请日：2004-03-10

申请人： Merck & Co., Inc.

发明人： BELL, Ian, M. ,  GRAHAM, Samuel, L. ,  WILLIAMS, Theresa, M. ,  STUMP, Craig, A.

IPC分类号： C07D403/12 ,  A61K31/55

CPC分类号： C07D403/12 ,  C07D235/02

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP1045843A1

公开(公告)日：2000-10-25

申请号：EP98960545.6

申请日：1998-11-30

申请人： MERCK & CO., INC.

发明人： CICCARONE, Terrence, M. ,  HALCZENKO, Wasyl ,  HUTCHINSON, John, H. ,  LUMMA, William, C., Jr. ,  STOKKER, Gerald, E. ,  STUMP, Craig, A. ,  WILLIAMS, Theresa, M.

IPC分类号： C07D401/02 ,  A61K31/415 ,  A61K31/47

摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemoterapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

摘要翻译： 本发明涉及抑制法尼基蛋白转移酶（FTase）和癌基因蛋白Ras的法尼基化的化合物。 本发明还涉及含有本发明化合物的化学治疗组合物以及用于抑制法尼基蛋白转移酶和癌基因蛋白Ras的法尼基化的方法。

公开(公告)号：EP1035850A1

公开(公告)日：2000-09-20

申请号：EP98960529.0

申请日：1998-11-30

申请人： MERCK & CO., INC.

发明人： HALCZENKO, Wasyl ,  STUMP, Craig, A.

IPC分类号： A61K31/44 ,  C07D471/04

CPC分类号： C07D495/04 ,  C07D471/04

摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

公开(公告)号：EP1951251A2

公开(公告)日：2008-08-06

申请号：EP06844350.6

申请日：2006-11-14

申请人： Merck & Co., Inc.

发明人： BELL, Ian, M. ,  STUMP, Craig, A. ,  THEBERGE, Cory, R. ,  WOOD, Michael, R. ,  ZARTMAN, C. Blair

IPC分类号： A61K31/55 ,  C07D487/10

CPC分类号： C07D487/10 ,  C07D471/10 ,  C07D519/00

摘要： Compounds of formula (I); (wherein variables A1, A2. A3, A4, A5, A6, A7, B3 E1, E2, E3, E4, E5, G1, G2 and R.6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP1951051A2

公开(公告)日：2008-08-06

申请号：EP06827801.9

申请日：2006-11-14

申请人： Merck & Co., Inc.

发明人： BELL, Ian, M. ,  STUMP, Craig, A. ,  THEBERGE, Cory, R. ,  GALLICCHIO, Steven, N. ,  ZARTMAN, C. Blair

IPC分类号： A01N43/62 ,  A61K31/55

CPC分类号： C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP1796678A2

公开(公告)日：2007-06-20

申请号：EP05795301.0

申请日：2005-09-09

申请人： Merck & Co., Inc.

发明人： WILLIAMS, Theresa, M. ,  BURGEY, Christopher, S. ,  TUCKER, Thomas, J. ,  STUMP, Craig, A. ,  BELL, Ian, M.

IPC分类号： A61K31/55

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D413/12 ,  C07D519/00

摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：EP2146712A1

公开(公告)日：2010-01-27

申请号：EP08742844.7

申请日：2008-04-11

申请人： Merck & Co., Inc.

发明人： BELL, Ian, M. ,  SELNICK, Harold, G. ,  STUMP, Craig, A.

IPC分类号： A61K31/44

CPC分类号： C07D471/20

摘要： Compounds of formula I: I (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.