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公开(公告)号：EP0946183A1
公开(公告)日：1999-10-06
申请号：EP97946363.0
申请日：1997-10-29
申请人： MERCK & CO., INC.
CPC分类号： A61K31/664 , A61K31/00 , A61K31/50 , A61K31/66 , Y10S514/821
摘要： A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.
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公开(公告)号：EP0948335B1
公开(公告)日：2007-05-23
申请号：EP97946362.7
申请日：1997-10-29
申请人： Merck & Co., Inc.
CPC分类号： C07F9/5333 , A61K31/00 , A61K31/50 , A61K31/66 , C07D237/24 , C07F9/532 , C07F9/5325
摘要： This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K+ current (I¿Kur?) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.
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公开(公告)号：EP1224265A1
公开(公告)日：2002-07-24
申请号：EP00968933.2
申请日：2000-10-10
申请人： Merck & Co., Inc.
IPC分类号： C12N5/10 , C12N15/12 , C12N15/63 , C12N15/64 , C07K14/705 , C07K14/71 , C07K16/18 , G01N33/53 , G01N33/567
CPC分类号： G01N33/6872 , C07K14/705
摘要： The present invention is directed to novel human DNA sequences encoding IsK2, a potassium channel subunit, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of potassium channels containing the human IsK2 subunit.
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公开(公告)号：EP1395602A2
公开(公告)日：2004-03-10
申请号：EP01989886.5
申请日：2001-11-02
申请人： Merck & Co., Inc.
IPC分类号： C07H21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is directed to novel human DNA sequences encoding Kvβ2.3, a potassium channel subunit, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of potassium channels containing the human Kvβ2.3 subunit.
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5.发明公开HUMAN HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CATION CHANNEL HCN3 审中-公开人类HYPER极化活化环核苷酸BASED阳离子通道HCN3
公开(公告)号：EP1358196A2
公开(公告)日：2003-11-05
申请号：EP01991006.6
申请日：2001-12-14
申请人： Merck & Co., Inc.
CPC分类号： C07K14/705
摘要： The present invention is directed to novel human DNA sequences encoding human HCN3 proteins, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and activators of cation channels containing the human HCN3 proteins.
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公开(公告)号：EP1224208A1
公开(公告)日：2002-07-24
申请号：EP00968530.6
申请日：2000-09-29
申请人： Merck & Co., Inc.
发明人： SWANSON, Richard, J. , LIU, Yuan , MCKENNA, Edward
CPC分类号： G01N33/6872 , C07K14/705
摘要： The present invention is directed to novel human DNA sequences encoding Kir5.1, a potassium channel subunit, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of potassium channels containing the human Kir5.1 subunit.
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7.发明授权USE OF PYRIDAZINONE OR PHOSPHINE OXIDE COMPOUNDS TO TREAT OR PREVENT CARDIAC ARRHYTHMIA 失效或使用哒膦化合物用于心脏治疗心律失常
公开(公告)号：EP0946183B1
公开(公告)日：2007-05-02
申请号：EP97946363.5
申请日：1997-10-29
申请人： Merck & Co., Inc.
CPC分类号： A61K31/664 , A61K31/00 , A61K31/50 , A61K31/66 , Y10S514/821
摘要： A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.
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公开(公告)号：EP1517917A2
公开(公告)日：2005-03-30
申请号：EP01995166.4
申请日：2001-11-16
申请人： Merck & Co., Inc.
IPC分类号： C07K14/435
CPC分类号： C07K14/705
摘要： The present invention is directed to novel human DNA sequences encoding h-erg2 proteins, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and activators of potassium channels containing the h-erg2 proteins.
摘要翻译： 本发明涉及编码h-erg2蛋白质的新型人DNA序列，由该DNA序列编码的蛋白质，包含该DNA序列的载体，含有该载体的宿主细胞，以及鉴定含有h-erg2蛋白质的钾通道抑制剂和活化剂的方法， erg2蛋白。
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9.发明公开HUMAN HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CATION CHANNEL HCN1 审中-公开人类HYPER极化活化BY环核苷酸控制的阳离子通道HCN1
公开(公告)号：EP1407011A2
公开(公告)日：2004-04-14
申请号：EP02720890.9
申请日：2002-01-18
申请人： Merck & Co., Inc.
IPC分类号： C12N15/00
CPC分类号： C07K14/705
摘要： The present invention is directed to novel human DNA sequences encoding human HCN1 proteins, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and activators of cation channels containing the human HCN1 proteins.
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公开(公告)号：EP0948335A1
公开(公告)日：1999-10-13
申请号：EP97946362.0
申请日：1997-10-29
申请人： MERCK & CO., INC.
CPC分类号： C07F9/5333 , A61K31/00 , A61K31/50 , A61K31/66 , C07D237/24 , C07F9/532 , C07F9/5325
摘要： This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K+ current (I¿Kur?) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.
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