专利检索 ap:("Merck & Co., Inc." OR "ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A." OR "MERCK SHARP & DOHME LTD.") AND inv:"MAHAJAN, Amar, J." 第 1 页

1.

发明公开
POTASSIUM SALT OF AN HIV INTEGRASE INHIBITOR 有权
标题翻译：钾盐的HIV整合酶抑制剂

公开(公告)号：EP1819683A2

公开(公告)日：2007-08-22

申请号：EP05852866.2

申请日：2005-12-02

申请人： Merck & Co., Inc. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , MERCK SHARP & DOHME LTD.

发明人： BELYK, Kevin, M. , MORRISON, Henry, G. , JONES, Philip , SUMMA, Vincenzo , COOPER, V., Brett , MAHAJAN, Amar, J. , KUMKE, Daniel, J. , TUNG, Hsien-Hsin , WAI, Lawrence , PRUZINSKY, Vanessa , PYE, Philip , ANGELAUD, Remy , MANCHENO, Danny

IPC分类号： C07D239/557 , C07D413/12 , A61K31/513 , A61P31/18

CPC分类号： C07D239/557 , C07D313/12 , C07D413/12

摘要： Potassium salts of Coompound A and methods for their preparation are disclosed, wherein Compound A is of formula: (Compound A). Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.

2.

发明公开
SODIUM SALT OF AN HIV INTEGRASE INHIBITOR 审中-公开
标题翻译： HIV整合酶抑制剂的钠盐

公开(公告)号：EP1430058A1

公开(公告)日：2004-06-23

申请号：EP02794880.1

申请日：2002-08-13

申请人： Merck & Co., Inc.

发明人： ANTHONY, Neville, J. , XU, Wei , LEPORE, John, V. , MAHAJAN, Amar, J.

IPC分类号： C07D487/06 , A61K31/4375 , A61P31/18

CPC分类号： C07D487/04

摘要： A sodium salt of Compound A is disclosed, wherein Compound A is of formula: (I) Compound ACompound A is an HIV integrase inhibitor useful for preventing or treating HIV infection, for delaying the onset of AIDS, and for treating AIDS.

3.

发明公开
CRYSTALLINE FORMS OF CARBAPENEM ANTIBIOTICS AND METHODS OF PREPARATION 审中-公开
标题翻译：碳青霉烯类抗生素和方法晶形

公开(公告)号：EP1442038A2

公开(公告)日：2004-08-04

申请号：EP02768879.5

申请日：2002-09-20

申请人： Merck & Co., Inc.

发明人： BRANDS, Karel, M., J. , CVETOVICH, Raymond , CROCKER, Louis, S. , WARD, Michael, D. , MAHAJAN, Amar, J. , WENSLOW, Robert, M. , WILLIAMS, John, M. , SIDLER, Daniel, R. , FISHER, Elizabeth, S. , JOBSON, Ronald , ORELLA, Charles

IPC分类号： C07D477/20

CPC分类号： C07D477/20

摘要： A process for preparing a crystalline, carbapenem monosodium salt of formula IIa, characterized by the steps a) adding about 10 to 30 % of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5 °C, c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25 °C.