公开(公告)号：EP1341784A2

公开(公告)日：2003-09-10

申请号：EP01992059.4

申请日：2001-12-04

申请人： Merck & Co., Inc. ,  MERCK SHARP & DOHME LTD.

发明人： DOLLING, Ulf, H. ,  ALABASTER, Ramon, J. ,  ASHWOOD, Michael, S. ,  COTTRELL, Ian, F. ,  COWDEN, Cameron, J. ,  DAVIES, Antony, J. ,  HANDS, David ,  WALLACE, Debra, J. ,  WILSON, Robert, D.

IPC分类号： C07D401/14 ,  A61K31/4427 ,  A61P7/02 ,  C07D213/55 ,  C07D213/30 ,  C07D213/38 ,  C07D241/18 ,  C07D213/83 ,  C07D241/16 ,  C07D401/12 ,  C07D213/61 ,  C07C235/74

CPC分类号： C07D213/30 ,  C07C235/74 ,  C07D213/38 ,  C07D213/55 ,  C07D213/61 ,  C07D213/83 ,  C07D213/84 ,  C07D241/16 ,  C07D241/18 ,  C07D401/12 ,  C07D401/14

摘要： The invention is a process for preparing 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide which comprises coupling with 2-aminomethyl-3-fluoropyridine dihydrochloric acid salt in the presence of a coupling reagent and a base to form 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide.