专利检索 ap:("Merck & Co., Inc." OR "Merck Sharp & Dohme de Espana S.A.E.") AND inv:"JUSTICE, Michael, C." 第 1 页

1.

发明公开
A NOVEL SORDARIN DERIVATIVE ISOLATED FROM CULTURE FERMENTATIONS AND FUNCTIONS AS AN ANTIFUNGAL AGENT 有权
标题翻译：新FROM KULTURFERMENTIERUNGEN隔离和效果SORDARINDERIVAT作为抗真菌剂

公开(公告)号：EP1458725A1

公开(公告)日：2004-09-22

申请号：EP02786991.6

申请日：2002-12-10

申请人： Merck & Co., Inc. , Merck Sharp & Dohme de Espana S.A.E.

发明人： GUAN, Ziqiang , HARRIS, Guy, H. , JUSTICE, Michael, C. , NIELSEN-KAHN, Jennifer , SHASTRY, Mythili, S. , BASILIO, Angela , COLLADO, Javier , DIEZ, Maria Teresa

IPC分类号： C07D493/10 , A61K31/365 , A61K31/335

CPC分类号： C07D493/10 , A61K31/522 , A61K31/7048 , A61K31/7072 , A61K31/7076

摘要： A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.

2.

发明授权
A NOVEL SORDARIN DERIVATIVE ISOLATED FROM CULTURE FERMENTATIONS AND FUNCTIONS AS AN ANTIFUNGAL AGENT 有权
标题翻译：新FROM KULTURFERMENTIERUNGEN隔离和效果SORDARINDERIVAT作为抗真菌剂

公开(公告)号：EP1458725B1

公开(公告)日：2007-02-21

申请号：EP02786991.6

申请日：2002-12-10

申请人： Merck & Co., Inc. , Merck Sharp & Dohme de Espana S.A.

发明人： GUAN, Ziqiang , HARRIS, Guy, H. , JUSTICE, Michael, C. , NIELSEN-KAHN, Jennifer , SHASTRY, Mythili, S. , BASILIO, Angela , COLLADO, Javier , DIEZ, Maria Teresa

IPC分类号： C07D493/10 , A61K31/365 , A61K31/335 , A01N43/00 , A61P31/10 , C12N1/14

CPC分类号： C07D493/10 , A61K31/522 , A61K31/7048 , A61K31/7072 , A61K31/7076

摘要： A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.

3.

发明公开
PROTEIN ELONGATION FACTOR 2 AS A TARGET FOR ANTIFUNGAL AND ANTIPARASITIC AGENTS 失效
标题翻译：蛋白质延伸因子2靶向分子抗真菌和抗寄生虫CONNECTIONS

公开(公告)号：EP0995120A1

公开(公告)日：2000-04-26

申请号：EP98928944.2

申请日：1998-06-09

申请人： MERCK & CO., INC.

发明人： NIELSEN-KAHN, Jennifer , JUSTICE, Michael, C. , SCHMATZ, Dennis, M. , HSU, Ming-Jo , KU, Theresa, W.

IPC分类号： G01N33/543

CPC分类号： C12Q1/18 , G01N33/56961

摘要： Inhibition of protein elongation factor (2) provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.