公开(公告)号：EP1458725A1

公开(公告)日：2004-09-22

申请号：EP02786991.6

申请日：2002-12-10

申请人： Merck & Co., Inc. ,  Merck Sharp & Dohme de Espana S.A.E.

发明人： GUAN, Ziqiang ,  HARRIS, Guy, H. ,  JUSTICE, Michael, C. ,  NIELSEN-KAHN, Jennifer ,  SHASTRY, Mythili, S. ,  BASILIO, Angela ,  COLLADO, Javier ,  DIEZ, Maria Teresa

IPC分类号： C07D493/10 ,  A61K31/365 ,  A61K31/335

CPC分类号： C07D493/10 ,  A61K31/522 ,  A61K31/7048 ,  A61K31/7072 ,  A61K31/7076

摘要： A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.

公开(公告)号：EP1007031A1

公开(公告)日：2000-06-14

申请号：EP98940966.9

申请日：1998-08-18

申请人： MERCK & CO., INC.

发明人： NIELSEN-KAHN, Jennifer ,  TSE, Bruno

IPC分类号： A61K31/34 ,  A61K31/35 ,  C07D307/77 ,  C07D309/10 ,  C07D311/94 ,  C07D317/46

CPC分类号： C07H15/24

摘要： 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.

摘要翻译： 4-氰基-4-去甲酰基桑丹碱衍生物是用于治疗和/或预防人和动物真菌感染以及控制作物中的植物病原性真菌的抗真菌剂。

公开(公告)号：EP1124813B1

公开(公告)日：2003-12-03

申请号：EP99955148.4

申请日：1999-10-22

申请人： MERCK & CO., INC.

发明人： STURR, Michael, G. ,  CHARTRAIN, Michel, M. ,  HARRIS, Guy, H. ,  NIELSEN-KAHN, Jennifer ,  HEIMBUCH, Brian

IPC分类号： C07D309/02 ,  C07H15/256 ,  C12P19/44

CPC分类号： C07D309/10

摘要： Biotransformation product of a fermentation with Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.

公开(公告)号：EP0995120A1

公开(公告)日：2000-04-26

申请号：EP98928944.2

申请日：1998-06-09

申请人： MERCK & CO., INC.

发明人： NIELSEN-KAHN, Jennifer ,  JUSTICE, Michael, C. ,  SCHMATZ, Dennis, M. ,  HSU, Ming-Jo ,  KU, Theresa, W.

IPC分类号： G01N33/543

CPC分类号： C12Q1/18 ,  G01N33/56961

摘要： Inhibition of protein elongation factor (2) provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.

公开(公告)号：EP1458725B1

公开(公告)日：2007-02-21

申请号：EP02786991.6

申请日：2002-12-10

申请人： Merck & Co., Inc. ,  Merck Sharp & Dohme de Espana S.A.

发明人： GUAN, Ziqiang ,  HARRIS, Guy, H. ,  JUSTICE, Michael, C. ,  NIELSEN-KAHN, Jennifer ,  SHASTRY, Mythili, S. ,  BASILIO, Angela ,  COLLADO, Javier ,  DIEZ, Maria Teresa

IPC分类号： C07D493/10 ,  A61K31/365 ,  A61K31/335 ,  A01N43/00 ,  A61P31/10 ,  C12N1/14

CPC分类号： C07D493/10 ,  A61K31/522 ,  A61K31/7048 ,  A61K31/7072 ,  A61K31/7076

摘要： A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.

公开(公告)号：EP1007031B1

公开(公告)日：2003-06-04

申请号：EP98940966.9

申请日：1998-08-18

申请人： MERCK & CO., INC.

发明人： NIELSEN-KAHN, Jennifer ,  TSE, Bruno

IPC分类号： A61K31/34 ,  A61K31/35 ,  C07D307/77 ,  C07D309/10 ,  C07D311/94 ,  C07D317/46 ,  C07H15/24

CPC分类号： C07H15/24

摘要： 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.

公开(公告)号：EP1124813A1

公开(公告)日：2001-08-22

申请号：EP99955148.4

申请日：1999-10-22

申请人： MERCK & CO., INC.

发明人： STURR, Michael, G. ,  CHARTRAIN, Michel, M. ,  HARRIS, Guy, H. ,  NIELSEN-KAHN, Jennifer ,  HEIMBUCH, Brian

IPC分类号： C07D309/02

CPC分类号： C07D309/10

摘要： Biotransformation product of a fermentation with Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.