公开(公告)号：EP1040098B1

公开(公告)日：2005-04-27

申请号：EP98963136.1

申请日：1998-12-14

申请人： Merck & Co., Inc. (a New Jersey corp.)

发明人： ASKEW, Ben, C. ,  COLEMAN, Paul, J. ,  DUGGAN, Mark, E. ,  HALCZENKO, Wasyl ,  HARTMAN, George, D. ,  HUNT, Cecilia ,  HUTCHINSON, John, H. ,  MEISSNER, Robert, S. ,  PATANE, Michael, A. ,  SMITH, Garry, R. ,  WANG, Jiabing

IPC分类号： C07D213/30 ,  C07D235/12 ,  C07D239/26 ,  C07D257/00 ,  C07D277/00 ,  C07D471/04 ,  C07D471/14 ,  A61K31/155 ,  A61K31/415 ,  A61K31/44 ,  A61K31/505 ,  C07D401/12 ,  C07D491/04 ,  C07D401/06 ,  C07D519/00 ,  C07D213/74

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D471/04 ,  C07D495/04

公开(公告)号：EP1040098A1

公开(公告)日：2000-10-04

申请号：EP98963136.1

申请日：1998-12-14

申请人： Merck & Co., Inc. (a New Jersey corp.)

发明人： ASKEW, Ben, C. ,  COLEMAN, Paul, J. ,  DUGGAN, Mark, E. ,  HALCZENKO, Wasyl ,  HARTMAN, George, D. ,  HUNT, Cecilia ,  HUTCHINSON, John, H. ,  MEISSNER, Robert, S. ,  PATANE, Michael, A. ,  SMITH, Garry, R. ,  WANG, Jiabing

IPC分类号： C07D213/30

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αξβ3, αξβ5, and/or αξβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.