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公开(公告)号：EP2190811A1
公开(公告)日：2010-06-02
申请号：EP08783392.7
申请日：2008-08-18
发明人： JUTEAU, Helene , GALLANT, Michel , DUBE, Daniel , ROY, Patrick , ASPIOTIS, Renee , FORTIN, Rejean , LACOMBE, Patrick , MCKAY, Daniel , WU, Tom, Yao-Hsiang
IPC分类号： C07C217/54 , A61K31/137 , A61K31/16 , A61K31/21 , A61K31/277 , A61K31/44 , C07C233/00 , C07C237/00 , C07C255/00 , C07C271/00 , C07D213/04
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as well as their use and method of treatment of cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及式（I）的联苯化合物。 这些化合物是非肽类的低分子量肾素抑制剂。 本发明进一步涉及含有所述化合物的药物组合物，以及它们的用途和治疗心血管事件和肾功能不全的方法。
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公开(公告)号：EP2162436A1
公开(公告)日：2010-03-17
申请号：EP08757142.8
申请日：2008-05-23
发明人： WU, Tom, Yao-Hsiang , JUTEAU, Helene , GALLANT, Michel , DUBE, Daniel , ROY, Patrick , ASPIOTIS, Renee , GRIMM, Erich, L. , LALIBERTE, Sebastien , CHEN, Austin
IPC分类号： C07D211/60 , A61K31/451 , A61K31/4523 , A61K31/5377 , A61P13/10 , A61P9/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.
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公开(公告)号：EP1954290A2
公开(公告)日：2008-08-13
申请号：EP06837799.3
申请日：2006-11-17
发明人： TRUCHON, Jean-Francois , LACHANCE, Nicolas , LAU, Cheuk , LEBLANC, Yves , MELLON, Christophe , ROY, Patrick , ISABEL,Elise , OTTE, Ryan, D. , YOUNG, Jonathan, R.
IPC分类号： A61K31/551 , C07D487/02
CPC分类号： C07D491/10 , C07D471/04
摘要： The present invention provides inhibitors of kinases, specifically IκB kinases, JAKl , JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-κB-mediated diseases.
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公开(公告)号：EP1558614B1
公开(公告)日：2010-09-01
申请号：EP03809672.3
申请日：2003-10-28
发明人： LEBLANC, Yves , DUFRESNE, Claude , ROY, Patrick
IPC分类号： C07D471/14 , A61K31/4375 , A61P29/00 , A61P11/00
CPC分类号： C07D471/14
摘要： Pyridopyrrolizine and pyridoindolizine derivatives are prostaglandin receptor antagonists useful for the treatment of prostaglandin-mediated diseases such as allergic rhinitis, nasal congestion and asthma.
摘要翻译： 吡啶并吡咯嗪和吡啶并吲嗪衍生物是前列腺素受体拮抗剂，可用于治疗前列腺素介导的疾病，如过敏性鼻炎，鼻塞和哮喘。
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公开(公告)号：EP1758865A1
公开(公告)日：2007-03-07
申请号：EP05754860.4
申请日：2005-06-07
发明人： LACHANCE, Nicolas , ROY, Patrick , LEBLANC, Yves
IPC分类号： C07D221/04 , C07D215/48 , A61K31/435 , A61K31/47 , A61P37/00 , C07D241/40 , C07D239/70 , A61K31/498 , A61K31/517
CPC分类号： C07D221/04 , C07D215/48
摘要： The present invention provides novel compounds of Formula I which are antagonists of the C5a receptor. Compounds of the present invention are useful for the treatment of various C5a-mediated diseases and disorders; accordingly the present invention provides a method for the treatment of C5a-mediated diseases using the novel compounds described herein, as well as pharmaceutical compositions containing them.
摘要翻译： 本发明提供了作为C5a受体拮抗剂的式I的新化合物。 本发明的化合物可用于治疗各种C5a介导的疾病和病症; 因此本发明提供了使用本文所述新化合物治疗C5a介导的疾病的方法，以及含有它们的药物组合物。
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