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1.发明授权5-AMINOALKYL-PYRAZOLO[4,3-D]PYRIMIDINE MIT PHOSPHODIESTERASE V INHIBIERENDER WIRKUNG 有权5-AMINOALKYL-PYRAZOLO [4,3-D] PYRIMININE MIT PHOSPHODIESTERASE V INHIBIERENDER WIRKUNG
公开(公告)号：EP1296986B1
公开(公告)日：2011-08-10
申请号：EP01957901.0
申请日：2001-06-28
申请人： Merck Patent GmbH
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00 , A61P15/10
CPC分类号： C07D487/04
摘要： The invention relates to 5-aminomethyl-pyrazolo[4,3-d]pyrimidines of general formula (I), wherein the radicals R1 to R6 have the meanings given in the text. The compounds demonstrate a phosphodiesterase V-inhibiting effect and can be used for treating diseases of the cardiovascular system and for treating potency disorders.
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公开(公告)号：EP1036078B1
公开(公告)日：2007-05-09
申请号：EP98964411.7
申请日：1998-11-19
申请人： Merck Patent GmbH
IPC分类号： C07D495/04 , A61K31/505 , C07D333/00 , C07D239/00
CPC分类号： C07D495/04
摘要： The invention relates to thienopyrimidines of formula (I) wherein R?1, R2, R3, R4¿, X and n have the meanings given in claim 1, and to their physiologically compatible salts. Said thienopyrimidines and their salts display a phosphodiesterase V-inhibition and can be used for treating diseases of the cardiovascular system and for treating and/or as a therapy for disturbances in potency.
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公开(公告)号：EP1432715A2
公开(公告)日：2004-06-30
申请号：EP02800556.9
申请日：2002-09-05
申请人： MERCK PATENT GmbH
发明人： EGGENWEILER, Hans-Michael , BAUMGARTH, Manfred , SCHELLING, Pierre , BEIER, Norbert , CHRISTADLER, Maria
IPC分类号： C07D487/04 , C07D495/04 , A61K31/505 , A61P9/08
CPC分类号： C07D487/04 , C07D491/04
摘要： Pyrimidine derivatives of formula (I) and the physiologically acceptable salts thereof, where R?1, R2, R3, R4¿, W, X, Y and Z have the meanings given in claim 1, display a phosphodiesterase V inhibition and can be used for treatment of diseases of the coronary circulatory system and for treatment and/or therapy of potency disorders.
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公开(公告)号：EP0920431B1
公开(公告)日：2003-02-26
申请号：EP97940047.0
申请日：1997-07-30
申请人： MERCK PATENT GmbH
IPC分类号： C07D495/04 , A61K31/505
CPC分类号： C07D495/04
摘要： Thienopyrimidines of formula (I) and their physiologically harmless salts, in which R?1, R2, R3, R4¿, X and n have the meaning indicated in claim 1, present a phosphodiesterase V-Inhibition activity and can be used in the treatment of cardio-vascular disorders and in impotence therapy.
摘要翻译： 式（I）的噻吩并嘧啶及其生理上无害的盐，其中R 1，R 2，R 3，R 4'，X和n具有权利要求1中所述的含义，呈现磷酸二酯酶V-抑制活性并可用于治疗 心血管疾病和阳痿治疗。
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5.发明公开AMINOTHIOPHENCARBONSÄUREAMIDE UND IHRE VERWENDUNG ALS PHOSPHODIESTERASE INHIBITOREN 失效AMINOTHIOPHENCARBONSÄUREAMIDE及其作为磷酸二酯酶抑制剂
公开(公告)号：EP0934301A1
公开(公告)日：1999-08-11
申请号：EP97912140.0
申请日：1997-10-08
申请人： MERCK PATENT GmbH
CPC分类号： C07D409/12 , C07D333/38 , C07D333/68
摘要： Aminothiophene carboxylic acid amides having formula (I) and their physiologically harmless salts, wherein R?1, R2, R3, R4, R5¿, A and n have the meaning given in claim 1, demonstrate phosphodiesterase V inhibition and can be used to treat cardiovascular diseases and in therapy for disturbances of potency.
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公开(公告)号：EP1351962B1
公开(公告)日：2005-03-16
申请号：EP01974106.5
申请日：2001-08-03
申请人： MERCK PATENT GmbH
发明人： JONAS, Rochus , EGGENWEILER, Hans-Michael , SCHELLING, Pierre , CHRISTADLER, Maria , BEIER, Norbert
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to thienopyrimidines of formula (I) and the physiologically tolerable salts thereof, wherein R1, R2 and X have the designation cited in patent claim 1. Said compounds exhibit a phosphodiesterase V inhibition and can be used to treat illnesses of the cardiovascular system. They can also be used for treating, and/or as therapy for, potency problems.
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公开(公告)号：EP0934321A1
公开(公告)日：1999-08-11
申请号：EP97912139.0
申请日：1997-10-08
申请人： MERCK PATENT GmbH
CPC分类号： C07D495/04
摘要： The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically acceptable salts, wherein R?1, R2, R3, R4¿, X and n have the meaning cited in Claim 1. Said compounds exhibit a phosphodiesterase V inhibition and can be used in the treatment of cardiovascular diseases and for the treatment and/or therapy potency disorders.
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公开(公告)号：EP0920431A1
公开(公告)日：1999-06-09
申请号：EP97940047.0
申请日：1997-07-30
申请人： MERCK PATENT GmbH
CPC分类号： C07D495/04
摘要： Thienopyrimidines of formula (I) and their physiologically harmless salts, in which R?1, R2, R3, R4¿, X and n have the meaning indicated in claim 1, present a phosphodiesterase V-Inhibition activity and can be used in the treatment of cardio-vascular disorders and in impotence therapy.
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9.发明公开2,1,3-BENZOTHIA(OXA)DIAZOLDERIVATE MIT ENDOTHELINREZEPTOR-ANTAGONISTISCHER WIRKUNG 失效与内皮素受体拮抗剂活性-2,1,3- BENZOTHIA（OXA）DIAZOLDERIVATE
公开(公告)号：EP0882030A1
公开(公告)日：1998-12-09
申请号：EP97905065.0
申请日：1997-02-20
申请人： MERCK PATENT GmbH
发明人： DORSCH, Dieter , OSSWALD, Mathias , MEDERSKI, Werner , WILM, Claudia , SCHMITGES, Claus , CHRISTADLER, Maria , ANZALI, Soheila
CPC分类号： C07D285/14 , C07D271/12 , C07D417/04 , C07D417/14
摘要： The invention concerns compounds of formula (I), in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R?1, R2, R3 and R4¿ have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.
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公开(公告)号：EP0796250A1
公开(公告)日：1997-09-24
申请号：EP96933341.0
申请日：1996-09-19
申请人： MERCK PATENT GmbH
发明人： DORSCH, Dieter , OSSWALD, Mathias , MEDERSKI, Werner , WILM, Claudia , SCHMITGES, Claus, Jochen , CHRISTADLER, Maria
IPC分类号： A61K31 , A61P9 , A61P11 , A61P13 , A61P15 , C07D237 , C07D285 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D405/06 , C07D237/04 , C07D237/14 , C07D413/06 , C07D417/06
摘要： Novel compounds of formula (I), wherein R?1, R2, R3¿ and Y have the meanings indicated in claim 1, and their salts, have endothelin-receptor antagonistic properties.
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