-
公开(公告)号：EP1257573B1
公开(公告)日：2006-10-11
申请号：EP01921282.8
申请日：2001-02-20
申请人： Merck Patent GmbH
发明人： KLUXEN, Franz-Werner
CPC分类号： C07K14/4702
摘要： CARP-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CARP-2 polypeptides and polynucleotides in diagnostic assays.
-
公开(公告)号：EP1287138A1
公开(公告)日：2003-03-05
申请号：EP01951553.5
申请日：2001-06-02
申请人： MERCK PATENT GmbH
CPC分类号： C07K14/723 , C07K2319/00
摘要： LTDrec polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LTDrec polypeptides and polynucleotides in diagnostic assays.
摘要翻译： 公开了多肽和多核苷酸以及通过重组技术生产这些多肽的方法。 还公开了在诊断测定中利用LTDrec多肽和多核苷酸的方法。
-
公开(公告)号：EP0934321A1
公开(公告)日：1999-08-11
申请号：EP97912139.0
申请日：1997-10-08
申请人： MERCK PATENT GmbH
CPC分类号： C07D495/04
摘要： The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically acceptable salts, wherein R?1, R2, R3, R4¿, X and n have the meaning cited in Claim 1. Said compounds exhibit a phosphodiesterase V inhibition and can be used in the treatment of cardiovascular diseases and for the treatment and/or therapy potency disorders.
-
公开(公告)号：EP0922036A1
公开(公告)日：1999-06-16
申请号：EP97937540.0
申请日：1997-08-01
申请人： MERCK PATENT GmbH
IPC分类号： A61K31 , A61P11 , A61P29 , A61P37 , A61P43 , C07D237 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D401/12 , C07D237/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Arylalkanoyl pyridazine derivatives of formula (I) as well as their physiologically harmless salts, wherein R1, R2, Q and B have the meanings indicated in claim 1, present a phosphodiesterase IV inhibition and can be employed to treat inflammatory processes such as allergies, asthma and autoimmune disorders.
摘要翻译： 式（I）的芳基烷酰基哒嗪衍生物及其生理上无害的盐，其中R1，R2，Q和B具有权利要求1中所述的含义，呈现磷酸二酯酶IV抑制作用，并可用于治疗炎症过程如变态反应，哮喘 和自身免疫性疾病。
-
公开(公告)号：EP0920431A1
公开(公告)日：1999-06-09
申请号：EP97940047.0
申请日：1997-07-30
申请人： MERCK PATENT GmbH
CPC分类号： C07D495/04
摘要： Thienopyrimidines of formula (I) and their physiologically harmless salts, in which R?1, R2, R3, R4¿, X and n have the meaning indicated in claim 1, present a phosphodiesterase V-Inhibition activity and can be used in the treatment of cardio-vascular disorders and in impotence therapy.
-
公开(公告)号：EP1084125B1
公开(公告)日：2005-12-28
申请号：EP99919263.6
申请日：1999-04-23
申请人： Merck Patent GmbH
IPC分类号： C07D495/04 , A61K31/505 , A61K31/38
CPC分类号： C07D495/04
摘要： The invention relates to thienopyrimidines of the formula (I) and their physiologically compatible salts, where R1, R2 and X have the meanings given in claim 1. These thienopyrimidines have a phosphodiesterase-V inhibiting action and can be used for the treatment of cardiovascular diseases and for the preventive and/or curative treatment of impotence.
-
公开(公告)号：EP1292679A1
公开(公告)日：2003-03-19
申请号：EP01960311.7
申请日：2001-06-15
申请人： MERCK PATENT GmbH
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： GPRMDA12 polypeptides and polnucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GPRMDA12 polypeptides and polynucleotides in diagnostic assays.
-
公开(公告)号：EP1235859A1
公开(公告)日：2002-09-04
申请号：EP00977506.5
申请日：2000-11-08
申请人： MERCK PATENT GmbH
发明人： KLUXEN, Franz-Werner
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： HTENQ40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTENQ40 polypeptides and polynucleotides in diagnostic assays.
-
公开(公告)号：EP1232265A2
公开(公告)日：2002-08-21
申请号：EP00989854.5
申请日：2000-11-14
申请人： MERCK PATENT GmbH
发明人： KLUXEN, Franz-Werner
CPC分类号： C07K14/705 , C07K2319/00
摘要： HTOGH35 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTOGH35 polypeptides and polynucleotides in diagnostic assays.
-
公开(公告)号：EP1087946A1
公开(公告)日：2001-04-04
申请号：EP99939760.7
申请日：1999-05-07
申请人： MERCK PATENT GmbH
IPC分类号： C07D237/04 , C07D405/04 , A61K31/50
CPC分类号： C07D405/04 , C07D237/04
摘要： The invention relates to aryl alkanoylpyridazine derivatives of the formula (I) and their physiologically compatible salts and solvates, where R1, R2, Q and B have the meanings given in claim 1. Said compounds have a phosphodiesterase-IV inhibiting action and can be used in the treatment of allergic disorders, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disturbances, atherosclerosis and AIDS.
摘要翻译： 本发明涉及式（I）和它们的生理学上相容的盐和溶剂化的芳基alkanoylpyridazine衍生物，其中R1，R2，Q和B具有权利要求1中给出的含义所述化合物具有磷酸二酯酶IV抑制作用，可用于 在过敏性疾病，哮喘，慢性支气管炎，特应性皮炎，银屑病和其它皮肤疾病，炎性疾病，自身免疫疾病，如类风湿关节炎，多发性硬化症，克罗恩氏病，糖尿病或溃疡性结肠炎，骨质疏松症，移植排斥反应的治疗 ，恶病质，肿瘤生长或肿瘤转移，败血症，记忆障碍，动脉粥样硬化和AIDS。
-
-
-
-
-
-
-
-
-
搜索结果
38 条记录 (耗时 0.019 秒)
