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1.发明授权ARYLPYRAZINONE DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权ARYLPYRAZINONDERIVATE ALS INSULINAUSSCHEIDUNGSSTIMULATOREN，用于治疗糖尿病的生产工艺和用途
公开(公告)号：EP2268624B1
公开(公告)日：2013-07-31
申请号：EP09737783.2
申请日：2009-03-31
申请人： Merck Patent GmbH
IPC分类号： C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
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2.发明公开PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权吡啶并呋喃酮衍生物胰岛素分泌促进剂，获得它们的方法及其用于治疗糖尿病的方法
公开(公告)号：EP2247292A1
公开(公告)日：2010-11-10
申请号：EP09717128.4
申请日：2009-02-27
申请人： Merck Patent GmbH
IPC分类号： A61K31/4985 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrazinone derivatives of formula (I), wherein X, Y, Z1 W, A and R1 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyridopyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡啶并吡嗪酮衍生物，其中X，Y，Z，W，A和R1如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡啶并吡嗪酮衍生物用于预防和/或治疗糖尿病和相关疾病的制备和用途。
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公开(公告)号：EP1685122B1
公开(公告)日：2008-07-09
申请号：EP04797711.1
申请日：2004-11-08
申请人： Merck Patent GmbH
IPC分类号： C07D333/64 , C07D307/83 , A61P29/00
CPC分类号： C07D333/64 , C07D307/83
摘要： The invention relates to compounds of the general formula (I), in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
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4.发明公开
公开(公告)号：EP1685121A1
公开(公告)日：2006-08-02
申请号：EP04790858.7
申请日：2004-10-26
申请人： Merck Patent GmbH
IPC分类号： C07D333/64 , C07D307/83 , A61K31/381 , A61K31/343
CPC分类号： A61K31/381 , A61K31/343 , C07D333/68 , C07D333/70
摘要： The invention relates to compounds of the general formula (I) in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
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5.发明授权
公开(公告)号：EP0918759B1
公开(公告)日：2002-08-28
申请号：EP97925034.7
申请日：1997-06-02
申请人： MERCK PATENT GmbH
发明人： MOINET, Gérard , BOTTON, Gérard , PRUGNARD, Etienne , DOARE, Liliane , KERGOAT, Micheline , MESANGEAU, Didier
IPC分类号： C07D277/34
CPC分类号： C07D277/34
摘要： The invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The invention more precisely features novel 5-phenoxyalkyl 2,4-thiazolidinediketones of general formula (I): in which A represents one linear or branched alkylene group comprising 2 to 16 carbon atoms D represents one monocyclic, bycyclic or tricyclic, homocarbonaceous or heterocarbonaceous aromatic structure capable of enclosing one or several heteroatoms X represents the aromatic structure substituent and is as defined in claim 1 n is one integer ranging from 1 to 3 with the restriction that if A represents one butyl radical, (a) does not represent the 4-chlorophenyl group. The invention also disclosed tautomer, enantiomer, diastereoisomer and epimer forms of general formula (I) compounds, in free or salified form. The invention also discloses methods for obtaining general formula (I) compounds, their use as antidiabetic agents, and in the insulin resistance metabolic syndrome, as well as in the pharmaceutical compositions that contain general formula (I) compounds.
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6.发明公开ALPHA-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS 失效作为抗糖尿病药的α-（1-哌嗪基）乙酰氨基阿糖胞苷酸衍生物
公开(公告)号：EP1091947A1
公开(公告)日：2001-04-18
申请号：EP98939495.2
申请日：1998-06-08
申请人： MERCK PATENT GmbH
发明人： MOINET, Gérard , BOTTON, Gérard , PATEREAU, Gérard , DOARE, Liliane , KERGOAT, Micheline , MESANGEAU, Didier , BIERER, Donald, D.
IPC分类号： C07D295/15 , A61K31/495
CPC分类号： C07D295/15 , C07D317/68
摘要： The invention relates to compounds of general formula (I). These compounds are useful in the treatment of diabetes.
摘要翻译： 本发明涉及通式（I）的化合物。 这些化合物可用于治疗糖尿病。
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7.发明授权PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权吡啶并呋喃酮衍生物胰岛素分泌促进剂，获得它们的方法及其用于治疗糖尿病的方法
公开(公告)号：EP2247292B1
公开(公告)日：2017-04-12
申请号：EP09717128.4
申请日：2009-02-27
申请人： Merck Patent GmbH
IPC分类号： A61K31/4985 , C07D471/04
CPC分类号： C07D471/04
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8.发明授权PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权PYRAZINONDERIVATE ALS INSULINAUSSCHEIDUNGSSTIMULATOREN，用于治疗糖尿病的生产工艺和用途
公开(公告)号：EP2250156B1
公开(公告)日：2015-05-06
申请号：EP09718204.2
申请日：2009-01-15
申请人： Merck Patent GmbH
IPC分类号： C07D241/18 , A61K31/4965 , A61P3/10
CPC分类号： C07D241/08 , C07D241/18
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9.发明公开QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权CHINOXALINONDERIVATE ALS INSULINAUSSCHEIDUNGSSTIMULATOREN，用于治疗糖尿病的生产工艺和用途
公开(公告)号：EP2247580A1
公开(公告)日：2010-11-10
申请号：EP09718118.4
申请日：2009-01-15
申请人： Merck Patent GmbH
IPC分类号： C07D241/44 , C07D403/04 , C07D405/04 , A61K31/498 , A61P3/10
CPC分类号： C07D413/10 , C07D241/44 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10
摘要： The present invention relates to quinoxalinone derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these quinoxalinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated. Other preferred compounds are compounds of general formula (I), wherein R1, R2, R3, R4, R5 and R6 can be optionally substituted by one or more groups selected from Z.
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公开(公告)号：EP1685122A1
公开(公告)日：2006-08-02
申请号：EP04797711.1
申请日：2004-11-08
申请人： Merck Patent GmbH
IPC分类号： C07D333/64 , C07D307/83 , A61P29/00
CPC分类号： C07D333/64 , C07D307/83
摘要： The invention relates to compounds of the general formula (I), in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
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