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9 条记录 (耗时 0.019 秒)

    OXAZOLOBENZIMIDAZOLE DERIVATIVES
    6.
    发明公开
    OXAZOLOBENZIMIDAZOLE DERIVATIVES 审中-公开

    公开(公告)号：EP2346334A1

    公开(公告)日：2011-07-27

    申请号：EP09816710.9

    申请日：2009-09-16

    申请人： Merck Sharp & Dohme Corp.

    发明人： CONVERSO, Antonella ,  HARTINGH, Timothy, John ,  STACHURA, Sylwia

    IPC分类号： A01N43/76 ,  A61K31/42

    CPC分类号： C07D498/04 ,  C07D498/14

    摘要： The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

    AHCY HYDROLASE INHIBITORS FOR TREATMENT OF HYPER HOMOCYSTEINEMIA
    7.
    发明公开
    AHCY HYDROLASE INHIBITORS FOR TREATMENT OF HYPER HOMOCYSTEINEMIA 审中-公开
    AHCY水解酶抑制剂治疗高同型半胱氨酸血症

    公开(公告)号：EP2334179A1

    公开(公告)日：2011-06-22

    申请号：EP09812090.0

    申请日：2009-08-31

    申请人： Merck Sharp & Dohme Corp.

    发明人： CONVERSO, Antonella ,  FRALEY, Mark, E. ,  HARTINGH, Timothy, J.

    IPC分类号： A01N43/04

    CPC分类号： C07D471/04

    摘要： The present invention is directed to AHCY inhibitors of formula (I): which are useful in the treatment of diseases characterized by high homocysteine levels, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases characterized by high homocysteine levels.

    摘要翻译： 本发明涉及式（I）的AHCY抑制剂：其可用于治疗特征在于高半胱氨酸水平高的疾病，例如阿尔茨海默氏病。 本发明还涉及包含所述化合物的药物组合物，并涉及所述化合物和组合物在治疗特征在于高同型半胱氨酸水平的疾病中的用途。

    OXAZOLOBENZIMIDAZOLE DERIVATIVES
    8.
    发明公开
    OXAZOLOBENZIMIDAZOLE DERIVATIVES 审中-公开
    恶唑代苯并咪唑衍生物

    公开(公告)号：EP2291078A1

    公开(公告)日：2011-03-09

    申请号：EP09747248.4

    申请日：2009-05-08

    申请人： Merck Sharp & Dohme Corp.

    发明人： BRNARDIC, Edward, J. ,  CONVERSO, Antonella ,  FRALEY, Mark, E. ,  GARBACCIO, Robert, M. ,  HUANG, Shaei, Y.

    IPC分类号： A01N43/50 ,  A01N43/76 ,  A61K31/42

    CPC分类号： C07D498/04

    摘要： The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

    摘要翻译： 本发明涉及作为代谢型谷氨酸受体增效剂的恶唑并苯并咪唑衍生物，特别是mGluR2受体，其可用于治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。